5-HTP

product on market Tablet or Pill Nature's Way Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

L-5-Hydroxytryptophan is used to support serotonin production, while Vitamin B6 acts as a cofactor in this synthesis process. Research provides moderate evidence for the efficacy of 5-HTP in mood regulation. Vitamin C provides general antioxidant support, though evidence for its specific synergy in this formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
30
Servings
Other Combinations
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Total Carbohydrates
1 Gram(s) (1% DV)
Vitamin C
120 mg (133% DV)
8 mg (471% DV)
6.2× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)

Other Ingredients

Cellulose Maltodextrin Sodium Croscarmellose Stearic Acid Silica Ethylcellulose Sodium Alginate Medium Chain Triglyceride Oleic Acid
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Recommendation: Adults take 1-2 tablets three times daily with meals, or as recommended by a healthcare professional.

Warnings & Precautions

Warning: Do not take this product if you are under 12 years of age, or if you are pregnant or nursing.

Warning: Do not take this product if you are under 12 years of age, or if you are pregnant or nursing. Do not take this product if you have or are taking medication for epilepsy, scleroderma, or Parkinson's disease, or if you are taking anti-depressants. If you are taking any medications, consult a healthcare professional before use.

If you suffer from gastrointestinal (GI) disorders such as ulcers, irritable bowel syndrome, Crohn's disease, ulcerative colitis, or celiac disease, you should not use 5-HTP. Some individuals may experience gastrointestinal (GI) upset including abdominal cramping, nausea, or diarrhea while taking this product. If discomfort persists, discontinue use. This product may cause drowsiness; do not drive or operate heavy machinery while taking this product.

Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing.

Formulation Notes

Helps make serotonin to support a positive mood

5-HTP provides neurotransmitter-production support Naturally produced by the body from the amino acid tryptophan 5-HTP With high potency vitamin B6 (per 2-tablet serving), a coenzyme to support neurotransmitter production.

Vegan Gelatin Free

Vegan Gelatin Free

L-5-Hydroxytryptophan Vitamins B6 & C 5-HTP from Griffonia seed extract 50 mg per tablet

Helps make serotonin to support a positive mood Enteric coated

Gluten free. No wheat, soy, dairy, gelatin, or artificial colors.

Bottled and tested in the USA

Additional Information

Vegan Gelatin Free

Bottle made from 50% post-consumer recycled plastic

Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.

Questions? 1-800-962-8873 / naturesway.com

Metadata

Product Details

UPC / SKU0 33674 45250 9
DSLD Entry Date2025-05-21
Product TypeOther Combinations
FormTablet or Pill
DSLD ID332135
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.