5-HTP

product on market Tablet or Pill Nature's Way 🟢 Safety: 100/100
Brand: Nature's Way
🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Tablet(s) Serving Size
30 Servings
Other Combinations Product Type
50% Evidence Coverage

Supplement Facts — Evidence Check

Total Carbohydrates
1 Gram(s) (1% DV)
Vitamin C
120 mg (133% DV)
8 mg (471% DV)
📊 6.2× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 8mg UL 100mg
100 mg
📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)
This product: 100mg

Other Ingredients

Cellulose Maltodextrin Sodium Croscarmellose Stearic Acid Silica Ethylcellulose Sodium Alginate Medium Chain Triglyceride Oleic Acid

Label Claims — Verification

❓ Nutrient
❓ All Other
❓ Structure/Function
All Other (99% of products) Structure/Function (78% of products) Nutrient (52% of products)

Target Groups

Children 4 or More Years of Age Vegan Vegetarian Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Recommendation: Adults take 1-2 tablets three times daily with meals, or as recommended by a healthcare professional.

⚠️ Warnings & Precautions

Warning: Do not take this product if you are under 12 years of age, or if you are pregnant or nursing.

Warning: Do not take this product if you are under 12 years of age, or if you are pregnant or nursing. Do not take this product if you have or are taking medication for epilepsy, scleroderma, or Parkinson's disease, or if you are taking anti-depressants. If you are taking any medications, consult a healthcare professional before use.

If you suffer from gastrointestinal (GI) disorders such as ulcers, irritable bowel syndrome, Crohn's disease, ulcerative colitis, or celiac disease, you should not use 5-HTP. Some individuals may experience gastrointestinal (GI) upset including abdominal cramping, nausea, or diarrhea while taking this product. If discomfort persists, discontinue use. This product may cause drowsiness; do not drive or operate heavy machinery while taking this product.

Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing.

🧪 Formulation Notes

Helps make serotonin to support a positive mood

5-HTP provides neurotransmitter-production support Naturally produced by the body from the amino acid tryptophan 5-HTP With high potency vitamin B6 (per 2-tablet serving), a coenzyme to support neurotransmitter production.

Vegan Gelatin Free

Vegan Gelatin Free

L-5-Hydroxytryptophan Vitamins B6 & C 5-HTP from Griffonia seed extract 50 mg per tablet

Helps make serotonin to support a positive mood Enteric coated

Gluten free. No wheat, soy, dairy, gelatin, or artificial colors.

Bottled and tested in the USA

Additional Information

Vegan Gelatin Free

Bottle made from 50% post-consumer recycled plastic

Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.

Questions? 1-800-962-8873 / naturesway.com

Product Details

UPC / SKU 0 33674 45250 9
DSLD Entry Date 2025-05-21
Product Type Other Combinations
Form Tablet or Pill
Brand Nature's Way
DSLD ID 332135
Data Updated 2026-04-11

Research Evidence

21 Research Sources
53 Avg Quality Score
11 Systematic Review
6 Rct
4 Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018
PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001
PubMed Cochrane
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002
PubMed Cochrane
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024
PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025
PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023
PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025
PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010
PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020
PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025
PubMed DOI
View all evidence for 5 Htp →

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