Bone Strength Collagen Formula by Life Extension — Ingredients, Evidence & Safety

Product Label

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Label Data

4 Capsule(s) Serving Size

30 Servings

Other Combinations Product Type

50% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin D3

25 mcg (125% DV)

✅ 1.7× RDA — within safe limits 📚 604 studies (Tier A: 16, B: 251)

RDA 0.015mg This product: 0.025mg UL 0.1mg

Calcium

300 mg (23% DV)

Magnesium

100 mg (24% DV)

📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)

This product: 100mg

Silicon

5 mg

📊 Market median: 108.0mg (8 products) 📚 9 studies (Tier A: 0, B: 4)

This product: 5mg

Plum Fruit Extract, Dry

100 mg

Fruitex B OsteoBoron

3 mg

📊 Market median: 3.0mg (58 products) 📚 2 studies — no high-quality reviews

This product: 3mg UL 20mg

Other Ingredients

Cellulose Stearate Maltodextrin Corn Starch

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (95% of products) Nutrient (80% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: Take four (4) capsules daily in divided doses, or as recommended by a healthcare practitioner.

⚠️ Warnings & Precautions

Read the entire label and follow the directions carefully prior to use.

Warnings Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

🧪 Formulation Notes

KoAct is a patented form of bone collagen with calcium designed to support bone strength and maintain optimal bone health.

Gluten free Non GMO Le Certified

Calcium Collagen Chelate

Additional Information

Scan for product info

Non GMO Le Certified

Store tightly closed in a cool, dry place.

Product Details

UPC / SKU 7 37870 17251 2

DSLD Entry Date 2025-03-25

Product Type Other Combinations

Form Capsule

Brand Life Extension

DSLD ID 328300

Data Updated 2026-04-11

Research Evidence

281 Research Sources

54 Avg Quality Score

141 Meta Analysis

72 Systematic Review

45 Rct

18 Clinical Trial

2 Narrative Review

1 Other

1 Guideline

1 Openfda Safety

A Vascular closure devices for femoral arterial puncture site haemostasis

Meta Analysis The Cochrane database of systematic reviews 2016

PubMed DOI

B Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis

Meta Analysis Nutrients 2023

PubMed DOI

B Transepithelial versus epithelium-off corneal crosslinking for progressive keratoconus

Meta Analysis The Cochrane database of systematic reviews 2021

PubMed DOI

B Bisphosphonate therapy for osteogenesis imperfecta

Meta Analysis The Cochrane database of systematic reviews 2014

PubMed DOI

B Punctal occlusion for dry eye syndrome

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI

B Dressings and topical agents containing hyaluronic acid for chronic wound healing

Systematic Review The Cochrane database of systematic reviews 2023

PubMed DOI

B Efficacy of statins for osteoporosis: a systematic review and meta-analysis

Meta Analysis Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2017

PubMed DOI

B Drugs to reduce bleeding and transfusion in major open vascular or endovascular surgery: a systematic review and network meta-analysis

Systematic Review The Cochrane database of systematic reviews 2023

PubMed DOI

B Bisphosphonate therapy for osteogenesis imperfecta

Meta Analysis The Cochrane database of systematic reviews 2008

PubMed DOI

B Bisphosphonates for osteoporosis in primary biliary cirrhosis

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI

View all evidence for Collagen →