🟢 80/100

This product is generally safe

  • Niacin: 75mg is 2.1× the Tolerable Upper Intake Level (35mg)
  • 50% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 75mg is 2.1× the Tolerable Upper Intake Level (35mg)

Label Data

1 Vegetable Capsule(s) Serving Size
60 Servings
Other Combinations Product Type
50% Evidence Coverage

Supplement Facts — Evidence Check

75 mg (469% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 2.1× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 75mg UL 35mg
40 mg
📊 Market median: 30.0mg (45 products)
Median 30.0mg This product: 40mg

Other Ingredients

Cellulose Ascorbyl Palmitate Rice Flour Silicon Dioxide

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (100% of products) Structure/Function (58% of products) Nutrient (4% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested use: Take 1 capsule in the morning or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Caution: Keep out of reach of children.

Professional Use Only

🧪 Formulation Notes

Pregnenolone Plus is a custom formula that provides Pregnenolone and the active precursor Niacinamide for ultimate delivery of Pregnenolone which is the key precursor pro-hormone involved in maintaining sufficient steroid hormone levels in the body. It plays a role in inflammatory control, sodium/potassium balance, sex hormone production and memory function and is the precursor (building-block) for all other hormones int he body including cortisol, DHEA, estrogen progesterone, testosterone, and aldosterone. Without Pregnenolone there can be no human steroid hormone production. Pregnenolone is known to modulate at least two key nerve receptor systems in the brain: NMDA receptors and GABA receptors. NMDA receptors are involved in learning, memory, and alertness. GABA receptors are involved in mood stability, relaxation, sex drive and sleep.

Pregnenolone Plus with activating Cofactor

Professional Grade

Free of: Wheat, gluten, corn, protein, soy, dairy products, artificial colors, sweeteners or preservatives.

Additional Information

Storage: Keep tightly closed in a cool, dry place.

GMP Good Manufacturing Practice Consistent Quality

Exclusive formula

Product Details

UPC / SKU 8 54998 00611 3
DSLD Entry Date 2025-03-25
Product Type Other Combinations
Form Capsule
DSLD ID 327700
Data Updated 2026-04-11

Research Evidence

9 Research Sources
38 Avg Quality Score
5 Rct
2 Narrative Review
2 Other
B Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans: A Randomized Clinical Trial
Rct JAMA network open 2020
C Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder
Rct Biomolecules 2022
C Pregnenolone for cognition and mood in dual diagnosis patients
Rct Psychiatry research 2010
C Reduced urine pregnenolone concentration after clinical response in patients with depression: An open-label short-term prospective study
Rct Psychoneuroendocrinology 2023
C Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia
Rct Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009
D Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells
Other The Journal of biological chemistry 2023
D Increased steroid hormone dehydroepiandrosterone and pregnenolone levels in post-mortem brain samples of alcoholics
Other Alcohol (Fayetteville, N.Y.) 2016
D Pregnenolone sulfate in the brain: a controversial neurosteroid
Narrative Review Neurochemistry international 2008
D Individual differences in cognitive aging: implication of pregnenolone sulfate
Narrative Review Progress in neurobiology 2003
View all evidence for Pregnenolone →

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