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Pregnenolone Plus

product on market Capsule Neurobiologix Safety: 80/100
80/100

This product is generally safe

  • Niacin: 75mg is 2.1× the Tolerable Upper Intake Level (35mg)
  • 50% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

Pregnenolone is a precursor hormone studied for cognitive support, though clinical evidence remains limited. Niacin is well-documented for supporting metabolic function and cellular energy. Overall, research coverage for this specific combination is minimal.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 75mg is 2.1× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for Pregnenolone Plus
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Vegetable Capsule(s)
Serving Size
60
Servings
Other Combinations
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

75 mg (469% DV)
Exceeds UL by 2.1× (UL: 35 mg) 196 studies (A:5, B:63)
40 mg
Market median: 30.0mg (45 products)

Other Ingredients

Cellulose Ascorbyl Palmitate Rice Flour Silicon Dioxide
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: Take 1 capsule in the morning or as directed by your healthcare practitioner.

Warnings & Precautions

Caution: Keep out of reach of children.

Professional Use Only

Formulation Notes

Pregnenolone Plus is a custom formula that provides Pregnenolone and the active precursor Niacinamide for ultimate delivery of Pregnenolone which is the key precursor pro-hormone involved in maintaining sufficient steroid hormone levels in the body. It plays a role in inflammatory control, sodium/potassium balance, sex hormone production and memory function and is the precursor (building-block) for all other hormones int he body including cortisol, DHEA, estrogen progesterone, testosterone, and aldosterone. Without Pregnenolone there can be no human steroid hormone production. Pregnenolone is known to modulate at least two key nerve receptor systems in the brain: NMDA receptors and GABA receptors. NMDA receptors are involved in learning, memory, and alertness. GABA receptors are involved in mood stability, relaxation, sex drive and sleep.

Pregnenolone Plus with activating Cofactor

Professional Grade

Free of: Wheat, gluten, corn, protein, soy, dairy products, artificial colors, sweeteners or preservatives.

Additional Information

Storage: Keep tightly closed in a cool, dry place.

GMP Good Manufacturing Practice Consistent Quality

Exclusive formula

Metadata

Product Details

UPC / SKU8 54998 00611 3
DSLD Entry Date2025-03-25
Product TypeOther Combinations
FormCapsule
DSLD ID327700
Data Updated2026-04-11
Research

Research Evidence

9
Research Sources
38
Avg Quality
5
Rct
2
Narrative Review
2
Other
B Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans: A Randomized Clinical Trial
Rct JAMA network open 2020 PubMed DOI
C Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder
Rct Biomolecules 2022 PubMed DOI
C Pregnenolone for cognition and mood in dual diagnosis patients
Rct Psychiatry research 2010 PubMed DOI
C Reduced urine pregnenolone concentration after clinical response in patients with depression: An open-label short-term prospective study
Rct Psychoneuroendocrinology 2023 PubMed DOI
C Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia
Rct Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009 PubMed DOI
D Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells
Other The Journal of biological chemistry 2023 PubMed DOI
D Increased steroid hormone dehydroepiandrosterone and pregnenolone levels in post-mortem brain samples of alcoholics
Other Alcohol (Fayetteville, N.Y.) 2016 PubMed DOI
D Pregnenolone sulfate in the brain: a controversial neurosteroid
Narrative Review Neurochemistry international 2008 PubMed
D Individual differences in cognitive aging: implication of pregnenolone sulfate
Narrative Review Progress in neurobiology 2003 PubMed
View all evidence for Pregnenolone →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.