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Pregnenolone

product on market Capsule Nature's Sunshine Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade
Label

Product Label

Label for Pregnenolone
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
30
Servings
Non-Nutrient/Non-Botanical
Product Type
0%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

20 mg
Market median: 30.0mg (45 products)

Other Ingredients

Cellulose Capsule
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

RECOMMENDATION Take one or two capsules daily with a meal. Drink one glass (8 oz) of water with the capsules.

Warnings & Precautions

KEEP OUT OF REACH OF CHILDREN.

DO NOT USE IF PREGNANT OR NURSING.

Consult a physician or licensed qualified health care professional before using the product if you have, or have a family history of, prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), or if you are using any other dietary supplement, prescription drug, or over-the-counter, drug. Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician or licensed qualified health care professional immediately if you are experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms.

This bottle was sealed for your protection. Do not use if inner seal is missing or damaged.

Warning: NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18 YEARS.

Additional Information

- Supports Memory, Mood and Joint Health* - Supports Female Glandular Balance*

©2011

01001824011111

GUARANTEED PURE

LOT:

Nature's Sunshine uses natural source materials in its products that are subject to color variation.

Nervous, Structural, and Glandular System Support

Pregnenolone is derived from Wild Yam root and supports brain health, memory, mood and energy production, hormonal balance, and joint health.*

Product of U.S.A.

Since 1972

QUALITY, SERVICE, INTEGRITY

Stock No. 1824-4

Metadata

Product Details

UPC / SKU0 99904 01824 2
DSLD Entry Date2012-01-25
Product TypeNon-Nutrient/Non-Botanical
FormCapsule
DSLD ID4595
Data Updated2026-04-11
Research

Research Evidence

9
Research Sources
38
Avg Quality
5
Rct
2
Narrative Review
2
Other
B Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans: A Randomized Clinical Trial
Rct JAMA network open 2020 PubMed DOI
C Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder
Rct Biomolecules 2022 PubMed DOI
C Pregnenolone for cognition and mood in dual diagnosis patients
Rct Psychiatry research 2010 PubMed DOI
C Reduced urine pregnenolone concentration after clinical response in patients with depression: An open-label short-term prospective study
Rct Psychoneuroendocrinology 2023 PubMed DOI
C Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia
Rct Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009 PubMed DOI
D Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells
Other The Journal of biological chemistry 2023 PubMed DOI
D Increased steroid hormone dehydroepiandrosterone and pregnenolone levels in post-mortem brain samples of alcoholics
Other Alcohol (Fayetteville, N.Y.) 2016 PubMed DOI
D Pregnenolone sulfate in the brain: a controversial neurosteroid
Narrative Review Neurochemistry international 2008 PubMed
D Individual differences in cognitive aging: implication of pregnenolone sulfate
Narrative Review Progress in neurobiology 2003 PubMed
View all evidence for Pregnenolone →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.