🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

📸

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Label Data

1 Capsule(s) Serving Size
30 Servings
Non-Nutrient/Non-Botanical Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

20 mg
📊 Market median: 30.0mg (45 products)
Median 30.0mg This product: 20mg

Other Ingredients

Cellulose Capsule

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (58% of products) Nutrient (4% of products)

Target Groups

Women (not pregnant or lactating)

Product Information

📋 Directions for Use

RECOMMENDATION Take one or two capsules daily with a meal. Drink one glass (8 oz) of water with the capsules.

⚠️ Warnings & Precautions

KEEP OUT OF REACH OF CHILDREN.

DO NOT USE IF PREGNANT OR NURSING.

Consult a physician or licensed qualified health care professional before using the product if you have, or have a family history of, prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), or if you are using any other dietary supplement, prescription drug, or over-the-counter, drug. Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician or licensed qualified health care professional immediately if you are experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms.

This bottle was sealed for your protection. Do not use if inner seal is missing or damaged.

Warning: NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18 YEARS.

Additional Information

- Supports Memory, Mood and Joint Health* - Supports Female Glandular Balance*

©2011

01001824011111

GUARANTEED PURE

LOT:

Nature's Sunshine uses natural source materials in its products that are subject to color variation.

Nervous, Structural, and Glandular System Support

Pregnenolone is derived from Wild Yam root and supports brain health, memory, mood and energy production, hormonal balance, and joint health.*

Product of U.S.A.

Since 1972

QUALITY, SERVICE, INTEGRITY

Stock No. 1824-4

Product Details

UPC / SKU 0 99904 01824 2
DSLD Entry Date 2012-01-25
Product Type Non-Nutrient/Non-Botanical
Form Capsule
DSLD ID 4595
Data Updated 2026-04-11

Research Evidence

9 Research Sources
38 Avg Quality Score
5 Rct
2 Narrative Review
2 Other
B Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans: A Randomized Clinical Trial
Rct JAMA network open 2020
C Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder
Rct Biomolecules 2022
C Pregnenolone for cognition and mood in dual diagnosis patients
Rct Psychiatry research 2010
C Reduced urine pregnenolone concentration after clinical response in patients with depression: An open-label short-term prospective study
Rct Psychoneuroendocrinology 2023
C Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia
Rct Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009
D Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells
Other The Journal of biological chemistry 2023
D Increased steroid hormone dehydroepiandrosterone and pregnenolone levels in post-mortem brain samples of alcoholics
Other Alcohol (Fayetteville, N.Y.) 2016
D Pregnenolone sulfate in the brain: a controversial neurosteroid
Narrative Review Neurochemistry international 2008
D Individual differences in cognitive aging: implication of pregnenolone sulfate
Narrative Review Progress in neurobiology 2003
View all evidence for Pregnenolone →

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