DHEA/Pregnenolone 50 mg/100 mg

product on market Capsule HoltraCeuticals 🟢 Safety: 100/100
Brand: HoltraCeuticals
🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

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Label Data

1 Capsule(s) Serving Size
100 Servings
Non-Nutrient/Non-Botanical Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

100 mg
📊 Market median: 30.0mg (45 products)
Median 30.0mg This product: 100mg
50 mg
📊 Market median: 50.0mg (57 products) 📚 17 studies — no high-quality reviews
This product: 50mg UL 50mg

Other Ingredients

Rice Dextrin Gelatin Magnesium Stearate

Label Claims — Verification

❓ All Other
❓ Structure/Function
All Other (100% of products) Structure/Function (58% of products) Nutrient (4% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Suggested Use: 1or more capsules per day or as directed by your physician.

⚠️ Warnings & Precautions

Keep out of reach of children.

Warning: Do not use if pregnant or nursing.

Not intended for use in persons under 18 years of age.

If you are taking prescription medications or have been diagnosed with an illness or disease, consult a physician before using this product.

Additional Information

Store in a cool, dry place protected from light.

*Adrenal and Metabolic Support

Product Details

UPC / SKU 8 37654 69365 0
DSLD Entry Date 2013-03-25
Product Type Non-Nutrient/Non-Botanical
Form Capsule
Brand HoltraCeuticals
DSLD ID 19400
Data Updated 2026-04-11

Research Evidence

9 Research Sources
38 Avg Quality Score
5 Rct
2 Narrative Review
2 Other
B Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans: A Randomized Clinical Trial
Rct JAMA network open 2020
PubMed DOI
C Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder
Rct Biomolecules 2022
PubMed DOI
C Pregnenolone for cognition and mood in dual diagnosis patients
Rct Psychiatry research 2010
PubMed DOI
C Reduced urine pregnenolone concentration after clinical response in patients with depression: An open-label short-term prospective study
Rct Psychoneuroendocrinology 2023
PubMed DOI
C Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia
Rct Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009
PubMed DOI
D Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells
Other The Journal of biological chemistry 2023
PubMed DOI
D Increased steroid hormone dehydroepiandrosterone and pregnenolone levels in post-mortem brain samples of alcoholics
Other Alcohol (Fayetteville, N.Y.) 2016
PubMed DOI
D Pregnenolone sulfate in the brain: a controversial neurosteroid
Narrative Review Neurochemistry international 2008
PubMed
D Individual differences in cognitive aging: implication of pregnenolone sulfate
Narrative Review Progress in neurobiology 2003
PubMed
View all evidence for Pregnenolone →

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