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DHEA/Pregnenolone 50 mg/100 mg

product on market Capsule HoltraCeuticals Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade
Label

Product Label

Label for DHEA/Pregnenolone 50 mg/100 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
100
Servings
Non-Nutrient/Non-Botanical
Product Type
0%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

100 mg
Market median: 30.0mg (45 products)
Market median: 50.0mg (57 products) 17 studies — no high-quality reviews

Other Ingredients

Rice Dextrin Gelatin Magnesium Stearate
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: 1or more capsules per day or as directed by your physician.

Warnings & Precautions

Keep out of reach of children.

Warning: Do not use if pregnant or nursing.

Not intended for use in persons under 18 years of age.

If you are taking prescription medications or have been diagnosed with an illness or disease, consult a physician before using this product.

Additional Information

Store in a cool, dry place protected from light.

*Adrenal and Metabolic Support

Metadata

Product Details

UPC / SKU8 37654 69365 0
DSLD Entry Date2013-03-25
Product TypeNon-Nutrient/Non-Botanical
FormCapsule
BrandHoltraCeuticals
DSLD ID19400
Data Updated2026-04-11
Research

Research Evidence

9
Research Sources
38
Avg Quality
5
Rct
2
Narrative Review
2
Other
B Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans: A Randomized Clinical Trial
Rct JAMA network open 2020 PubMed DOI
C Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder
Rct Biomolecules 2022 PubMed DOI
C Pregnenolone for cognition and mood in dual diagnosis patients
Rct Psychiatry research 2010 PubMed DOI
C Reduced urine pregnenolone concentration after clinical response in patients with depression: An open-label short-term prospective study
Rct Psychoneuroendocrinology 2023 PubMed DOI
C Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia
Rct Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009 PubMed DOI
D Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells
Other The Journal of biological chemistry 2023 PubMed DOI
D Increased steroid hormone dehydroepiandrosterone and pregnenolone levels in post-mortem brain samples of alcoholics
Other Alcohol (Fayetteville, N.Y.) 2016 PubMed DOI
D Pregnenolone sulfate in the brain: a controversial neurosteroid
Narrative Review Neurochemistry international 2008 PubMed
D Individual differences in cognitive aging: implication of pregnenolone sulfate
Narrative Review Progress in neurobiology 2003 PubMed
View all evidence for Pregnenolone →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.