Home/ Supplements/ Folate/ BioActive B12-Folate

BioActive B12-Folate

product on market Tablet or Pill Neurobiologix Safety: 80/100
80/100

This product is generally safe

  • Folate: 1360mg is 1360.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Folate and Vitamin B12 are essential for DNA synthesis and neurological function, with strong clinical evidence supporting their role in maintaining homocysteine levels. While these ingredients are well-researched, the specific evidence coverage for this formulation is limited. The profile maintains a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 1360mg is 1360.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for BioActive B12-Folate
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
60
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1360 mcg DFE (340% DV)
Exceeds UL by 1360.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
1000 mcg (41667% DV)
416.7× RDA — above typical dose 139 studies (A:1, B:44)

Other Ingredients

Mannitol Vegetable Stearine Silicon Dioxide Croscarmellose Sodium Stearic Acid
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Info

Product Information

Directions for Use

Suggested use: Dissolve 1 tablet daily in the mouth before swallowing or as directed by your healthcare practitioner.

Warnings & Precautions

Do not use if shrinkwrap is broken or missing.

Keep out of reach of children.

Professional Use Only

In case of adverse reaction, call 866-500-5388.

Formulation Notes

Bioactive B12-folate contains active forms of vitamin B12 and folate. The tablets are sweetened with mannitol and may be dissolved in the mouth and swallowed or swallowed whole if desired.

Metafolin

Produced under a strict quality management system in compliance with Good Manufacturing Practices (GMPs) and third-party quality certifications.

Bioactive nutrients

Additional Information

Store in a cool, dry place (59 degrees F- 85 degrees F) away from direct light.

Metadata

Product Details

UPC / SKU8 54998 00637 3
DSLD Entry Date2025-04-24
Product TypeVitamin
FormTablet or Pill
BrandNeurobiologix
DSLD ID327658
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
View all evidence for Folate →
Compare

Similar Products

Maximum Strength Folic Acid 800 mcg
Nature's Bounty · Tablet or Pill
100
Folic Acid 800 mcg
VitaCeutical Labs · Tablet or Pill
100
Folic Acid 800 mcg With 25 mcg Vitamin B-12
Vitabase · Tablet or Pill
100
Natural Folic Acid 400 mcg
Equaline · Tablet or Pill
100
Folic Acid 400 mcg Supplement
Nature Made · Tablet or Pill
100
View all Folate products →
Folate research Best Folate All Folate products More from Neurobiologix View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.