🟡 60/100

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  • Folate: 1360mg is 1360.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 1360mg is 1360.0× the Tolerable Upper Intake Level (1.0mg)

This product received a low safety score because the amount of folate it contains is significantly higher than the recommended maximum daily limit.

Label Data

1 Capsule(s) Serving Size
120 Servings
Vitamin Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

1360 mcg DFE (340% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1360.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 1360mg UL 1.0mg

Other Ingredients

Microcrystalline Cellulose Hydroxypropyl Methylcellulose Stearic Acid Magnesium Stearate Silicon Dioxide

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (77% of products) Nutrient (60% of products) Approved Health (5% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: Take one capsule per day or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Caution: Keep out of reach of children.

🧪 Formulation Notes

Methyl Folate contains Quatrefolic - the most biologically active form of folate - allowing rapid uptake into the bloodstream. This superior, methylated form of folate is metabolically active and ready for the body to use since it requires no additional conversion to be absorbed. Folate is also necessary for the conversion of homocysteine to methionine. The 5-MTHF in this formula is also known as the "L" form of 5-MTHF since it is the reduced form of folate.

This formula meets or exceeds cGMP Quality Standards.

Does not contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy.

Activated B-Vitamins Rapid Uptake 5-MTHF Bioactive Folate Featuring 5-MTHF as Quatrefolic As Quatrefolic 5-MTHF. Quatrefolic is a registered trademark of Gnosis S.p.A. Patent number 7,947,662.

GF Gluten-Free

Vegetarian

Additional Information

Storage: Keep tightly closed in a cool, dry place.

Professional quality formulas

Product Details

UPC / SKU 8 12527 01060 4
DSLD Entry Date 2025-03-25
Product Type Vitamin
Form Capsule
Brand NuMedica
DSLD ID 326166
Data Updated 2026-04-11

Research Evidence

363 Research Sources
57 Avg Quality Score
187 Meta Analysis
56 Systematic Review
54 Rct
29 Guideline
26 Clinical Trial
6 Cochrane Review
2 Regulatory Source
1 Other
1 Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025
View all evidence for Folate →

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