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Methyl Folate

product on market Capsule NuMedica Safety: 60/100
60/100

Review before taking

  • Folate: 1360mg is 1360.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Folate is essential for DNA synthesis and amino acid metabolism, with strong evidence supporting its role in supporting healthy homocysteine levels. However, the limited evidence coverage for this specific formulation and a safety score of 60 suggest potential concerns regarding dosage or purity. Users should exercise caution due to these safety considerations.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 1360mg is 1360.0× the Tolerable Upper Intake Level (1.0mg)

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product received a low safety score because it contains an amount of folate that significantly exceeds the recommended daily upper limit.

Label

Product Label

Label for Methyl Folate
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
120
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1360 mcg DFE (340% DV)
Exceeds UL by 1360.0× (UL: 1.0 mg) 226 studies (A:10, B:105)

Other Ingredients

Microcrystalline Cellulose Hydroxypropyl Methylcellulose Stearic Acid Magnesium Stearate Silicon Dioxide
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take one capsule per day or as directed by your healthcare practitioner.

Warnings & Precautions

Caution: Keep out of reach of children.

Formulation Notes

Methyl Folate contains Quatrefolic - the most biologically active form of folate - allowing rapid uptake into the bloodstream. This superior, methylated form of folate is metabolically active and ready for the body to use since it requires no additional conversion to be absorbed. Folate is also necessary for the conversion of homocysteine to methionine. The 5-MTHF in this formula is also known as the "L" form of 5-MTHF since it is the reduced form of folate.

This formula meets or exceeds cGMP Quality Standards.

Does not contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy.

Activated B-Vitamins Rapid Uptake 5-MTHF Bioactive Folate Featuring 5-MTHF as Quatrefolic As Quatrefolic 5-MTHF. Quatrefolic is a registered trademark of Gnosis S.p.A. Patent number 7,947,662.

GF Gluten-Free

Vegetarian

Additional Information

Storage: Keep tightly closed in a cool, dry place.

Professional quality formulas

Metadata

Product Details

UPC / SKU8 12527 01060 4
DSLD Entry Date2025-03-25
Product TypeVitamin
FormCapsule
BrandNuMedica
DSLD ID326166
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
View all evidence for Folate →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.