SAMe-200 200 mg by Progressive Professional from Progressive Laboratories — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Enteric Coated Tablet(s) Serving Size

30 Servings

Non-Nutrient/Non-Botanical Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

SAMe

200 mg

📊 Market median: 200.0mg (52 products) 📚 10 studies (Tier A: 0, B: 6)

This product: 200mg

Other Ingredients

Microcrystalline Cellulose Magnesium Hydroxide Stearic Acid Magnesium Stearate Colloidal Silica Anhydrous Calcium Oxide Magnesium Silicate Flake Shellac dewaxed Arginine Base Glycerol Colloidal Silica Anhydrous Magnesium Stearate Sodium Alginate

Label Claims — Verification

❓ All Other

All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Directions: One enteric coated tablet daily, on an empty stomach, or as directed by a health care professional.

⚠️ Warnings & Precautions

Pregnant and/or lactating women should consult their physician prior to use.

Tamper evident band around cap and seal on bottle. Do not use if either seal is broken or missing. Warning: Individuals being treated for neurological conditions should consult their health care practitioner before using this product. Individuals with bipolar (manic) depression should take SAMe only under professional medical supervision.

Keep out of reach of children.

Sold only by dispensing by a licensed health care professional.

🧪 Formulation Notes

Progressive Laboratories manufactured this product in its 3rd party GMP-inspected facility. (Good Manufacturing Practices)

200 mg S-Adenosyl-Methionine Enteric Coated

Additional Information

Certified GMP Complaint GMP Good Manufacturing Practices 21 CFR 111

Seal tightly after each use. Keep refrigerated.

Product Details

UPC / SKU 3 51821 04732 4

DSLD Entry Date 2025-02-23

Product Type Non-Nutrient/Non-Botanical

Form Tablet or Pill

Brand Progressive Professional from Progressive Laboratories

DSLD ID 323752

Data Updated 2026-04-11

Research Evidence

12 Research Sources

58 Avg Quality Score

8 Meta Analysis

3 Systematic Review

1 Rct

B S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2006

PubMed

B S-adenosyl methionine (SAMe) for depression in adults

Meta Analysis The Cochrane database of systematic reviews 2016

PubMed

B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease

Meta Analysis Annals of the rheumatic diseases 2024

PubMed DOI

B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis

Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024

PubMed DOI

B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis

Meta Analysis General hospital psychiatry 2024

PubMed DOI

B S-adenosyl-L-methionine for alcoholic liver diseases

Systematic Review The Cochrane database of systematic reviews 2001

PubMed

B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis