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SAMe-200 200 mg

product on market Tablet or Pill Progressive Professional from Progressive Laboratories Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

SAMe is researched for its role in supporting mood and joint health. There is moderate evidence suggesting its effectiveness in managing depressive symptoms and osteoarthritis. However, overall evidence coverage for this specific formulation remains limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for SAMe-200 200 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Enteric Coated Tablet(s)
Serving Size
30
Servings
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

200 mg
Market median: 200.0mg (52 products) 12 studies (A:0, B:6)

Other Ingredients

Microcrystalline Cellulose Magnesium Hydroxide Stearic Acid Magnesium Stearate Colloidal Silica Anhydrous Calcium Oxide Magnesium Silicate Flake Shellac dewaxed Arginine Base Glycerol Colloidal Silica Anhydrous Magnesium Stearate Sodium Alginate
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Directions: One enteric coated tablet daily, on an empty stomach, or as directed by a health care professional.

Warnings & Precautions

Pregnant and/or lactating women should consult their physician prior to use.

Tamper evident band around cap and seal on bottle. Do not use if either seal is broken or missing. Warning: Individuals being treated for neurological conditions should consult their health care practitioner before using this product. Individuals with bipolar (manic) depression should take SAMe only under professional medical supervision.

Keep out of reach of children.

Sold only by dispensing by a licensed health care professional.

Formulation Notes

Progressive Laboratories manufactured this product in its 3rd party GMP-inspected facility. (Good Manufacturing Practices)

200 mg S-Adenosyl-Methionine Enteric Coated

Additional Information

Certified GMP Complaint GMP Good Manufacturing Practices 21 CFR 111

Seal tightly after each use. Keep refrigerated.

Metadata

Product Details

UPC / SKU3 51821 04732 4
DSLD Entry Date2025-02-23
Product TypeNon-Nutrient/Non-Botanical
FormTablet or Pill
DSLD ID323752
Data Updated2026-04-11
Research

Research Evidence

12
Research Sources
58
Avg Quality
8
Meta Analysis
3
Systematic Review
1
Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024 PubMed DOI
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024 PubMed DOI
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024 PubMed DOI
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015 PubMed DOI
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024 PubMed DOI
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.