🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 40% of ingredients have research evidence
A Label Compliance Grade

Product Label

📸

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Label Data

2 Liquid Softgel(s) Serving Size
30 Servings
Other Combinations Product Type
40% Evidence Coverage

Supplement Facts — Evidence Check

Calories
10 Calorie(s)
Total Fat
1 Gram(s) (1% DV)
Protein
1 Gram(s)
2.5 mg (147% DV)
✅ 1.9× RDA — within safe limits 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 2.5mg UL 100mg
25 mcg (1042% DV)
📊 10.4× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.025mg
300 mcg (857% DV)
📊 8.6× RDA — above typical dose 📚 197 studies (Tier A: 1, B: 55)
RDA 0.035mg This product: 0.3mg
Aqtiv Medium Chain Triglyceride Oil
500 mg
500 mg
📊 Market median: 1000.0mg (212 products) 📚 12 studies (Tier A: 0, B: 3)
This product: 500mg
DNF-10 Yeast Hydrolysate
250 mg
BioPerine Complex
3 mg

Other Ingredients

Gelatin Water, Purified Glycerin Beeswax Maltodextrin Sunflower Lecithin Titanium Dioxide Mannitol Silicon Dioxide Caramel extract Red Cabbage extract

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (89% of products) Nutrient (56% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating)

Product Information

📋 Directions for Use

Directions: (Adult) Take two (2) liquid soft-gels, two times per day with a full glass (8oz) of water, and 30-minutes prior to your two biggest meals.

⚠️ Warnings & Precautions

Usage warnings: Do not use if safety seal is broken. This product contains ingredient(s) that may affect blood sugar. Do not exceed recommended daily intake.

Check with your doctor before using this product if you are using medication or have any medical conditions. Do not use if you may become pregnant, are pregnant or nursing.

Not intended for use by persons under 18. Keep out of reach of children.

Contains: Tree nut (coconut, palm kernel)

🧪 Formulation Notes

Balancing "calories in" with "calories out" is at the foundation of most weight management programs. In a world where we are surrounded by unhealthy, carbohydrate dense foods that look and taste amazing, this can be one of the hardest balancing acts to maintain and is often what causes weight loss efforts to lose momentum and disappear into the night... until now. Gut-to-brain hunger control is a unique weight management tool that addresses this core issue by helping you reduce calorie intake and carbohydrate cravings so that you can improved success in achieving your weight-loss goals. What makes us different: Liquid Soft-Gels - The nutrients in these easy-to-swallow liquid soft-gels are released fast. Other forms of delivery can contain binders and fillers that may cause stomach upset and offer no traditional value. Advanced Liquid Soft-Gels provide an optimum delivery system. Quality assurance - Irwin Naturals is committed to providing the highest quality products for your health. We employ compliance testing to ensure purity and potency.

DNF-10 satiety peptides This formula features DNF-10 satiety peptides, which has risen in popularity due to its potential to target the key hunger hormone Ghrelin. Preliminary research shows that DNF-10 can reduce the sensation of hunger and the impulse to eat carbohydrates helping to reduce fat mass and body mass index (BMI). Bonus features DNF-10 is complemented by the supportive effects of chromium, methylcobalamin (B12), Vitamin B6, and Medium Chain Triglycerides (MCTs), which combine to support cellular energy balance throughout the body. Patented BioPerine - Our special BioPerine Complex enhances the bioavailability, absorption and potency of many nutrients.

DNF-10 satiety peptides

Reduces hunger signals from the stomach to the brain, to help control carb cravings & calorie intake

No preservatives added.

Additional Information

Global responsibility - Over the years we have donated to organizations that support the environment and the health of children.

Pass Quality Tested Guaranteed

Store in a cool, dry place.

Questions: Contact consumer affairs Weekdays 8:00 AM to 5:00 PM (PST) 100+ highly specialized products: www.IrwinNaturals.com

Full Disclosure Ingredient Panel

Product Details

UPC / SKU 8 40081 40603 8
DSLD Entry Date 2025-02-23
Product Type Other Combinations
Form Softgel Capsule
DSLD ID 323283
Data Updated 2026-04-11

Research Evidence

237 Research Sources
53 Avg Quality Score
83 Meta Analysis
74 Systematic Review
45 Rct
29 Clinical Trial
2 Guideline
2 Regulatory Source
1 Openfda Safety
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency
Systematic Review The Cochrane database of systematic reviews 2018
A Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression
Meta Analysis Nutrients 2021
A Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis
Systematic Review Irish journal of medical science 2024
B Helicobacter pylori infection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis
Meta Analysis BMJ open gastroenterology 2020
B Vitamin B12 supplementation during pregnancy for maternal and child health outcomes
Systematic Review The Cochrane database of systematic reviews 2024
B A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels
Meta Analysis Nutrition reviews 2024
B Relationship between vitamin B12 levels and motor development: A systematic review
Systematic Review Clinical nutrition ESPEN 2024
B Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis
Meta Analysis Frontiers in endocrinology 2023
View all evidence for Vitamin B12 →

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