Home/ Supplements/ Folate/ B-6 B-12 Methyl Folate Mixed Berry

B-6 B-12 Methyl Folate Mixed Berry

product on market Tablet or Pill KAL Safety: 87/100
87/100

This product is generally safe

  • Folate: 400mg is 400.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Vitamin B6, B12, and folate are essential nutrients that support neurological function and homocysteine regulation. There is strong evidence for their role in maintaining cardiovascular and cognitive health. Due to the limited evidence coverage for this specific formulation, individual results may vary.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 400mg is 400.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for B-6 B-12 Methyl Folate Mixed Berry
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
60
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

3 mg (176% DV)
2.3× RDA — within safe limits 114 studies (A:3, B:35)
400 mcg DFE (100% DV)
Exceeds UL by 400.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
2500 mcg (104167% DV)
1041.7× RDA — above typical dose 139 studies (A:1, B:44)

Other Ingredients

Mannitol Starch Complex Sorbitol Mixed Berry Flavor, Natural Other Natural Flavors Polysaccharides Cellulose Stevia Leaf Extract Citric Acid Sodium Bicarbonate Magnesium Stearate Silica
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

1 Daily

Directions: Dissolve one ActivMelt micro tablet on or under the tongue daily. Use only as directed.

Warnings & Precautions

Warning: Do not use if safety seal is broken or missing. Keep your licensed health care practitioner informed when using this product.

Keep out of reach of children.

Formulation Notes

B-6 B-12 Folic Acid 3 mg/ 2500 mcg/ 400 mcg DFE Mixed Berry Natural Flavor

ActivMelt Instant Dissolve

Discussion: KAL B-6 B-12 Folate ActivMelt micro tablets melt quickly in the mouth and are designed for optimal absorption in the body. These Coenzyme B-vitamins are recognized as biologically active forms.

Vegetarian.

Additional Information

Store in a cool, dry place.

Metadata

Product Details

UPC / SKU0 21245 29151 0
DSLD Entry Date2024-12-21
Product TypeVitamin
FormTablet or Pill
BrandKAL
DSLD ID322893
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
View all evidence for Folate →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.