SAM-e by GNC TriFlex — Ingredients, Evidence & Safety

Product Label

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Label Data

3 Capsule(s) Serving Size

30 Servings

Non-Nutrient/Non-Botanical Product Type

43% Evidence Coverage

Supplement Facts — Evidence Check

Calories

5 {Calories}

Total Carbohydrates

1 g (1% DV)

Sodium

120 mg (5% DV)

Glucosamine Sulfate

1500 mg

📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)

This product: 1500mg

Chondroitin Sulfate Sodium

1200 mg

📊 Market median: 600.0mg (79 products) 📚 24 studies (Tier A: 0, B: 6)

This product: 1200mg

MSM

500 mg

📊 Market median: 1000.0mg (2 products)

This product: 500mg

SAM-e

100 mg

📊 Market median: 200.0mg (52 products) 📚 10 studies (Tier A: 0, B: 6)

This product: 100mg

Other Ingredients

Gelatin Silica Vegetable Magnesium Stearate

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (89% of products) Nutrient (16% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Directions: As a dietary supplement, take three capsules daily.

⚠️ Warnings & Precautions

Contains: Shellfish (shrimp).

Warning: Do not use if pregnant or nursing.

Do not exceed recommended dose.

If you are taking any medication or are under the care of a physician for depression or related disorder, contact your physician before using this product.

May cause gastrointestinal upset in some persons. If you experience discomfort, discontinue use.

Keep out of reach of children

🧪 Formulation Notes

Glucosamine Chondroitin MSM

Contains: Shellfish (shrimp).

No artificial colors, no artificial flavors, no wheat, no gluten, no yeast, no lactose, no milk or milk derivatives, no sugar.

Additional Information

Made in the USA Actual size

Promotes joint mobility & flexibility Clinically validated benefits

CODE 277012 AIG

Store in a cool, dry place.

Product Details

UPC / SKU 0 48107 06914 8

DSLD Entry Date 2011-12-23

Product Type Non-Nutrient/Non-Botanical

Form Capsule

Brand GNC TriFlex

DSLD ID 3203

Data Updated 2026-04-11

Research Evidence

39 Research Sources

50 Avg Quality Score

20 Rct

9 Meta Analysis

4 Clinical Trial

3 Systematic Review

1 Regulatory Source

1 Openfda Safety

B Interventions for the management of temporomandibular joint osteoarthritis

Systematic Review The Cochrane database of systematic reviews 2012

PubMed DOI Cochrane

B Glucosamine therapy for treating osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2005

PubMed Cochrane

B Chondroitin for osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI Cochrane

B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis

Meta Analysis Archives of orthopaedic and trauma surgery 2023

PubMed DOI

B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis

Rct The New England journal of medicine 2006

PubMed

B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review

Systematic Review International journal of molecular sciences 2023

PubMed DOI

B Scientific Opinion on glucosamine and joint health

Regulatory Source EFSA Journal 2009

DOI

B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis

Meta Analysis Computational and mathematical methods in medicine 2022

PubMed DOI

B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib

Rct Annals of the rheumatic diseases 2016

PubMed DOI

B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials

Meta Analysis Journal of orthopaedic surgery and research 2018

PubMed DOI

View all evidence for Glucosamine →