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SAM-e

product on market Capsule GNC TriFlex Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 43% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Glucosamine and chondroitin sulfate are commonly used to support joint health and cartilage maintenance. Research provides moderate evidence that these ingredients may help reduce joint discomfort and improve mobility. The overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for SAM-e
Open Full PDF View on NIH DSLD →
Details

Label Data

3 Capsule(s)
Serving Size
30
Servings
Non-Nutrient/Non-Botanical
Product Type
43%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
5 {Calories}
Total Carbohydrates
1 g (1% DV)
Sodium
120 mg (5% DV)
Market median: 1000.0mg (1115 products) 24 studies (A:0, B:9)
Market median: 600.0mg (79 products) 25 studies (A:0, B:6)
MSM
500 mg
Market median: 1000.0mg (2 products)
100 mg
Market median: 200.0mg (52 products) 12 studies (A:0, B:6)

Other Ingredients

Gelatin Silica Vegetable Magnesium Stearate
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement, take three capsules daily.

Warnings & Precautions

Contains: Shellfish (shrimp).

Warning: Do not use if pregnant or nursing.

Do not exceed recommended dose.

If you are taking any medication or are under the care of a physician for depression or related disorder, contact your physician before using this product.

May cause gastrointestinal upset in some persons. If you experience discomfort, discontinue use.

Keep out of reach of children

Formulation Notes

Glucosamine Chondroitin MSM

Contains: Shellfish (shrimp).

No artificial colors, no artificial flavors, no wheat, no gluten, no yeast, no lactose, no milk or milk derivatives, no sugar.

Additional Information

Made in the USA Actual size

Promotes joint mobility & flexibility Clinically validated benefits

CODE 277012 AIG

Store in a cool, dry place.

Metadata

Product Details

UPC / SKU0 48107 06914 8
DSLD Entry Date2011-12-23
Product TypeNon-Nutrient/Non-Botanical
FormCapsule
BrandGNC TriFlex
DSLD ID3203
Data Updated2026-04-11
Research

Research Evidence

39
Research Sources
50
Avg Quality
20
Rct
9
Meta Analysis
4
Clinical Trial
3
Systematic Review
1
Regulatory Source
1
Openfda Safety
B Interventions for the management of temporomandibular joint osteoarthritis
Systematic Review The Cochrane database of systematic reviews 2012 PubMed DOI
B Glucosamine therapy for treating osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2005 PubMed
B Chondroitin for osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis
Meta Analysis Archives of orthopaedic and trauma surgery 2023 PubMed DOI
B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
Rct The New England journal of medicine 2006 PubMed
B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review
Systematic Review International journal of molecular sciences 2023 PubMed DOI
B Scientific Opinion on glucosamine and joint health
Regulatory Source EFSA Journal 2009 DOI
B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis
Meta Analysis Computational and mathematical methods in medicine 2022 PubMed DOI
B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Rct Annals of the rheumatic diseases 2016 PubMed DOI
B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials
Meta Analysis Journal of orthopaedic surgery and research 2018 PubMed DOI
View all evidence for Glucosamine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.