Digestive Enzyme Formula by Puritan's Pride — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
8% of ingredients have research evidence

B Label Compliance Grade

Product Label

📄 Open Full PDF View on NIH DSLD →

📸

Have a supplement label? Find it here.

Upload a photo of any supplement label to search our database of 92,312 products.

Label Data

2 Caplet(s) Serving Size

60 Servings

Other Combinations Product Type

8% Evidence Coverage

Supplement Facts — Evidence Check

Calcium

150 mg (12% DV)

Phosphorus

118 mg (9% DV)

✅ Within RDA (0.2× RDA of 700 mg) 📚 12 studies (Tier A: 0, B: 3)

RDA 700mg This product: 118mg UL 4000mg

Betaine Hydrochloride

400 mg

📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews

This product: 400mg

Amylase

108 mg

Bromelain

80 mg

📊 Market median: 200.0mg (136 products) 📚 3 studies — no high-quality reviews

This product: 80mg

Peppermint Oil extract

50 mg

📊 Market median: 60.0mg (107 products) 📚 1 studies — no high-quality reviews

This product: 50mg

Protease

30 mg

Papain

20 mg

Pepsin

20 mg

Lipase

12.5 mg

Cellulase

10 mg

Pancreatin

4 mg

Other Ingredients

Dicalcium Phosphate Cellulose Tapioca Dextrin Maltodextrin Lactose Stearic Acid Silica Tapioca Starch, Modified Magnesium Stearate

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (85% of products) Nutrient (54% of products) Approved Health (3% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Directions: For adults, take two (2) caplets daily, preferably with a meal.

⚠️ Warnings & Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, including a known sensitivity to latex, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur. Do not use if seal under cap is broken or missing.

Keep out of reach of children.

Contains milk, wheat and soy ingredients.

🧪 Formulation Notes

This product contains natural enzymes that sometimes have a distinctive odor.

Digestive aid for proteins, fats and carbohydrates

Additional Information

Store at room temperature.

QA Quality Assured

To reorder Item # 13012 www.puritan.com 1-800-645-1030

Product Details

UPC / SKU 0 25077 13012 2

DSLD Entry Date 2024-09-25

Product Type Other Combinations

Form Other (e.g. tea bag)

Brand Puritan's Pride

DSLD ID 318302

Data Updated 2026-04-11

Research Evidence

849 Research Sources

56 Avg Quality Score

450 Meta Analysis

152 Rct

137 Systematic Review

73 Clinical Trial

11 Regulatory Source

7 Other

7 Guideline

3 Openfda Safety

2 Cochrane Review

2 Observational

A Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD)

Meta Analysis The Cochrane database of systematic reviews 2018

PubMed DOI Cochrane

A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes

Meta Analysis The Cochrane database of systematic reviews 2024

PubMed DOI Cochrane

A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI Cochrane

A Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life

Meta Analysis The Cochrane database of systematic reviews 2018

PubMed DOI Cochrane

A Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems

Meta Analysis The Cochrane database of systematic reviews 2025

PubMed DOI Cochrane

A Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps

Systematic Review The Cochrane database of systematic reviews 2008

PubMed DOI Cochrane

A Calcium and vitamin D for increasing bone mineral density in premenopausal women

Systematic Review The Cochrane database of systematic reviews 2023

PubMed DOI Cochrane

A Dietary sodium, sodium-to-potassium ratio, and risk of stroke: A systematic review and nonlinear dose-response meta-analysis

Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2019

PubMed DOI

A The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis

Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2021

PubMed DOI

A Calcium channel blockers versus other classes of drugs for hypertension

Systematic Review The Cochrane database of systematic reviews 2021

PubMed DOI

View all evidence for Electrolytes →