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Nicotinamide

product on market Capsule Dr. Seth's Safety: 60/100
60/100

Review before taking

  • Nicotinamide: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Nicotinamide is supported by strong evidence for improving skin barrier function and reducing inflammation. However, the low safety score suggests potential concerns regarding adverse reactions or toxicity at certain concentrations. Users should exercise caution due to these safety considerations.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Nicotinamide: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product received a low safety score because it contains 500mg of Nicotinamide, which is over 14 times the recommended upper limit for daily intake.

Label

Product Label

Label for Nicotinamide
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Veggie Capsule(s)
Serving Size
100
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

500 mg (2500% DV)
Exceeds UL by 14.3× (UL: 35 mg) 196 studies (A:5, B:63)

Other Ingredients

Cellulose Microcrystalline Cellulose Leucine
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: As a dietary supplement, take 1 veggie capsule daily, or as directed by your healthcare practitioner.

Warnings & Precautions

Warning: Do not use if pregnant or nursing.

If you are diabetic, have liver disease, or stomach ulcers, consult your healthcare practitioner before taking this product. It is recommended to discontinue use 2 weeks before any surgery.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Formulation Notes

Formulated to support energy production Metabolism Circulation Nerve & digestive function Synthesis of sex hormones Color of this product may vary due to color variations of the natural ingredients FDA Registered Facility USA Manuf. in USA w/ Global Ingred.

Supports energy production

GMP Good Manuf. Practices

Gluten Free

Vegetarian

Non Flush Niacin

Made w/ Non GMO Ingred. No Artificial Colors

Additional Information

Store sealed in a cool, dry place.

Metadata

Product Details

UPC / SKUX001KO1VR7
DSLD Entry Date2024-07-25
Product TypeVitamin
FormCapsule
BrandDr. Seth's
DSLD ID315778
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.