🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Vegetarian Capsule(s) Serving Size
60 Servings
Non-Nutrient/Non-Botanical Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

200 mg
📊 Market median: 200.0mg (52 products) 📚 10 studies (Tier A: 0, B: 6)
This product: 200mg

Other Ingredients

Hydroxypropyl Methylcellulose Gellan Gum Water Microcrystalline Cellulose Calcium Oxide Ascorbyl Palmitate Calcium Chloride

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Suggested Usage: As a dietary supplement, adults take 1 capsule, 1-2 times daily between meals or as directed by your health professional.

⚠️ Warnings & Precautions

Do not open capsules before consuming.

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, particularly if you have bipolar disorder or are taking antidepressant medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

🧪 Formulation Notes

This formula is manufactured in acid-resistant capsules that provide both protection and pH targeted release in intestinal fluid.

Gluten-free, Non-GMO

Support for methylation and healthy joints

Additional Information

Store in a cool, dry place.

Scan to learn about our manufacturing excellence Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

Product Details

UPC / SKU 3 10539 97758 3
DSLD Entry Date 2024-07-25
Product Type Non-Nutrient/Non-Botanical
Form Capsule
DSLD ID 313540
Data Updated 2026-04-11

Research Evidence

12 Research Sources
58 Avg Quality Score
8 Meta Analysis
3 Systematic Review
1 Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024
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