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R-Alpha Lipoic Acid with Biotin

product on market Capsule Jarrow Formulas Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

R-Alpha Lipoic Acid is a potent antioxidant that supports cellular energy metabolism, while biotin serves as a critical cofactor for enzyme function. Research provides moderate evidence for their roles in metabolic health and nerve function. However, overall evidence coverage for this specific combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for R-Alpha Lipoic Acid with Biotin
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
60
Servings
Other Combinations
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

150 mcg (500% DV)
5.0× RDA — above typical dose 27 studies (A:0, B:11)
Market median: 200.0mg (198 products) 6 studies — no high-quality reviews

Other Ingredients

Microcrystalline Cellulose Hydroxypropyl Methylcellulose Water Calcium Phosphate Silicon Dioxide Magnesium Stearate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: Adults take 1 capsule once a day or as directed by your qualified healthcare professional.

Warnings & Precautions

Warning: This product contains Biotin which may interfere with lab/blood tests. Do not use if safety seal is damaged or missing.

Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication or have a medical condition (especially if being treated for glucose control); if adverse reactions occur, discontinue use.

Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication or have a medical condition (especially if being treated for glucose control); if adverse reactions occur, discontinue use. Keep out of the reach of children.

Formulation Notes

Jarrow Formulas R-Alpha Lipoic Acid (Bio-Enhanced Na-RALA) exhibits high bioavailability and is the form of alpha lipoic acid found naturally in plants, animals, and the human body. RALA is an antioxidant and a cofactor in cellular energy production, as well as glucose and lipid metabolism. We have included d-Biotin in this formula because it helps to prevent biotin deficiency from long-term alpha lipoic acid use.

Vegan

High bioavailability Cofactor for cellular energy production, as well as glucose and lipid metabolism

Non-GMO Gluten free

No wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame. Non GMO Project Verified nongmoproject.org

Additional Information

Store in a cool, dry place.

Non GMO Project Verified nongmoproject.org

Energy

Metadata

Product Details

UPC / SKU7 90011 20039 0
DSLD Entry Date2024-01-24
Product TypeOther Combinations
FormCapsule
DSLD ID307722
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
52
Avg Quality
13
Rct
4
Meta Analysis
2
Systematic Review
2
Clinical Trial
A Alpha-lipoic acid for diabetic peripheral neuropathy
Systematic Review The Cochrane database of systematic reviews 2024 PubMed DOI
B Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy
Rct Nutrients 2024 PubMed DOI
B Alpha Lipoic Acid Supplementation and Iron Homeostasis: A Comprehensive Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Meta Analysis International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 2024 PubMed DOI
B Effectiveness of alpha-lipoic acid in patients with neuropathic pain associated with type I and type II diabetes mellitus: A systematic review and meta-analysis
Meta Analysis Medicine 2023 PubMed DOI
C The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Metabolism: clinical and experimental 2018 PubMed DOI
C A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy
Meta Analysis European journal of endocrinology 2012 PubMed DOI
C Oral Alpha Lipoic Acid Treatment for Symptomatic Diabetic Peripheral Neuropathy: A Randomized Double-Blinded Placebo-Controlled Study
Rct Endocrine, metabolic & immune disorders drug targets 2020 PubMed DOI
C A randomized, double-blind, placebo controlled study to evaluate the effect of alpha-lipoic acid on inhibition of ADP-and collagen-induced platelet aggregation ex vivo in diabetic neuropathy patients on gabapentin or pregabalin
Rct Journal of postgraduate medicine 2024 PubMed DOI
C Ranking Alpha Lipoic Acid and Gamma Linolenic Acid in Terms of Efficacy and Safety in the Management of Adults With Diabetic Peripheral Neuropathy: A Systematic Review and Network Meta-analysis
Systematic Review Canadian journal of diabetes 2024 PubMed DOI
C Effect analysis of tanshinone IIA sulfonate sodium combined with a-lipoic acid in patients with diabetes peripheral neuropathy.
Rct Pakistan journal of pharmaceutical sciences PubMed
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.