🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 33% of ingredients have research evidence
A Label Compliance Grade

Product Label

📸

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Label Data

2 Caplet(s) Serving Size
37 Servings
Other Combinations Product Type
33% Evidence Coverage

Supplement Facts — Evidence Check

Calories
10 {Calories}
Total Carbohydrates
2 Gram(s) (1% DV)
Sodium
20 mg (1% DV)
1500 mg
📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)
This product: 1500mg
Joint Shield(TM) Proprietary Blend
375 mg
📊 Market median: 100.0mg (283 products) 📚 142 studies (Tier A: 1, B: 64)
This product: 60mg UL 1200mg

Other Ingredients

Crospovidone Cellulose Contains <2% of

Label Claims — Verification

All Other
Qualified Health
Structure/Function
All Other (100% of products) Structure/Function (89% of products) Nutrient (16% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

DIRECTIONS FOR ADULT USE: TAKE TWO (2) CAPLETS PER DAY WITH FOOD.

⚠️ Warnings & Precautions

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

CAUTION: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18.

Contains shellfish (shrimp, crab, lobster, crayfish) ingredients.

KEEP OUT OF REACH OF CHILDREN.

🧪 Formulation Notes

GLUCOSAMINE CHONDROITIN

Contains shellfish (shrimp, crab, lobster, crayfish) ingredients.

Free of Gluten

So Osteo Bi-Flex(R) Joint & Muscle is specially formulated with Glucosamine, which is naturally produced in our body as a building block of joint cartilage, plus Co Q-10 for your muscles.*

Additional Information

Co Q-10 is an important bioenergetic compound naturally present in the muscle where its normal role is to support energy production from food.*

STORE AT ROOM TEMPERATURE AND AVOID EXCESSIVE HEAT.

#This statement is based on two human studies of 5-LOXIN(R) Advanced using subjective measures in which participants rate their joint health. In these studies, after 7 days, improvement continued to be seen, including in biomarker analysis.

^Based on results of a GfK Healthcare 2011 survey among physicians who recommend a brand of Glucosamine and Chondroitin or Glucosamine supplements; and the results of a Pharmacy Times Survey among pharmacists who recommend a “bone/joint strengthener” dietary supplement, 2006 -2012.

THE #1 DOCTOR & PHARMACIST RECOMMENDED BRAND!^

HELPS TO: >Support Joint Health* >Promote Mobility* >Provide a Natural Muscle Compound* >Revitalize Joints*

**52 week Nielsen ScanTrack data ending 6/30/12.

CONTAINS A NATURAL MUSCLE COMPOUND* HELP REVITALIZE YOUR JOINTS* KEY BUILDING BLOCK OF CARTILAGE*

2 PER DAY

ONLY 2 EASY-TO-SWALLOW CAPLETS help support cartilage and help with annoying flare-ups while supporting the cellular components within joints.* Starts Improving Joint Comfort in 7 Days*#

As a reminder, discuss the supplements and medications you take with your health care providers.

50972 01B B50972 LAB

40 POINTS

Osteo Bi-Flex(R) is manufactured under the highest standard for product quality, including purity and potency.

Every day joint cartilage breaks down and builds up. While we can’t reverse the aging process, we can take beneficial ingredients to comfort our joints.* Active joints need active joint...and muscle...support.** You work hard, play hard and demand a lot from your muscles and joints. Helping to keep them healthy now can help keep them healthy going forward as part of a continued joint care routine.* That’s why we created Osteo Bi-Flex(R) Joint & Muscle.

Every time you flex your knee, your muscles work together with your joints to make it happen.

Proud sponsor of the ARTHRITIS FOUNDATION(R)

Part No. 22-50972

Join the millions of people who choose Osteo Bi-Flex(R) for their joints every day, and have made it their #1 brand.

Product Details

UPC / SKU 0 30768 50972 9
DSLD Entry Date 2014-02-26
Product Type Other Combinations
Form Other (e.g. tea bag)
DSLD ID 30753
Data Updated 2026-04-11

Research Evidence

39 Research Sources
50 Avg Quality Score
20 Rct
9 Meta Analysis
4 Clinical Trial
3 Systematic Review
1 Regulatory Source
1 Openfda Safety
B Interventions for the management of temporomandibular joint osteoarthritis
Systematic Review The Cochrane database of systematic reviews 2012
B Glucosamine therapy for treating osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2005
B Chondroitin for osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2015
B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis
Meta Analysis Archives of orthopaedic and trauma surgery 2023
B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
Rct The New England journal of medicine 2006
B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review
Systematic Review International journal of molecular sciences 2023
B Scientific Opinion on glucosamine and joint health
Regulatory Source EFSA Journal 2009
B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis
Meta Analysis Computational and mathematical methods in medicine 2022
B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Rct Annals of the rheumatic diseases 2016
B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials
Meta Analysis Journal of orthopaedic surgery and research 2018
View all evidence for Glucosamine →

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