Home/ Supplements/ Folate/ Extra Strength L-Methyl Folate 15 mg

Extra Strength L-Methyl Folate 15 mg

product on market Capsule Nature's Truth Safety: 60/100
60/100

Review before taking

  • Folate: 25000mg is 25000.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

L-methyl folate is a bioactive form of folate used to support cellular methylation and neurological function, with strong evidence for its role in folate deficiency. However, the high dosage in this product may lead to safety concerns or masking of other deficiencies. Evidence coverage for this specific profile remains very limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 25000mg is 25000.0× the Tolerable Upper Intake Level (1.0mg)

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product received a low safety score because the amount of folate it contains significantly exceeds the recommended tolerable upper intake level.

Label

Product Label

Label for Extra Strength L-Methyl Folate 15 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Quick Release Capsule(s)
Serving Size
30
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

25000 mcg DFE (6250% DV)
Exceeds UL by 25000.0× (UL: 1.0 mg) 226 studies (A:10, B:105)

Other Ingredients

Rice, Powder Gelatin Magnesium Stearate Silica
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Info

Product Information

Directions for Use

Directions: For adults, take two (2) quick release capsules daily, preferably with a meal.

Warnings & Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Large quantities of methylfolate may mask the effects of pernicious anemia.

If any adverse reactions occur, immediately stop using this product and consult your doctor. If seal under cap is damaged or missing, do not use.

Keep out of reach of children.

Formulation Notes

L-Methylfolate 15mg per serving

Gluten free Non GMO

Metabolically active form of folic acid

No gluten, wheat, yeast, milk, lactose, soy, artificial color, artificial flavor, artificial sweetener, preservatives. Non-GMO

Our Non-GMO Pledge Visit our website

Additional Information

Vitamin

Store in a cool, dry place.

100% Quality Satisfaction guarantee

Metadata

Product Details

UPC / SKU8 40093 11666 6
DSLD Entry Date2024-07-25
Product TypeVitamin
FormCapsule
BrandNature's Truth
DSLD ID306687
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.