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Niacin 250 mg Time Release

product on market Capsule Sundown Naturals Safety: 60/100
60/100

Review before taking

  • Niacin: 250mg is 7.1× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Niacin is used to support cholesterol management and energy metabolism, though evidence for general wellness is limited. The time-release formulation may reduce flushing, but a safety score of 60 indicates potential concerns regarding liver toxicity or nutrient interactions. Users should be aware of these risks when supplementing with high doses.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 250mg is 7.1× the Tolerable Upper Intake Level (35mg)

AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product received a low safety score because the amount of Niacin is over seven times the recommended upper daily limit. Taking this much may exceed the level considered safe for most people.

Label

Product Label

Label for Niacin 250 mg Time Release
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

250 mg (1250% DV)
Exceeds UL by 7.1× (UL: 35 mg) 196 studies (A:5, B:63)

Other Ingredients

Gelatin Sucrose Corn Starch Food Glaze Magnesium Silicate
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

DIRECTIONS: FOR ADULTS, TAKE ONE (1) CAPSULE DAILY, PREFERABLY WITH A MEAL.

Do not take on an empty stomach.

Warnings & Precautions

NOTICE: Most people should not experience flushing when using this product. However a few sensitive individuals may experience some flushing.

WARNING: Not intended for use by pregnant or nursing women. If you are taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

KEEP OUT OF REACH OF CHILDREN.

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

Formulation Notes

No Artificial Sweetener, Color or Flavor, No Preservatives, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.

Additional Information

As a reminder, discuss the supplements and medications you take with your health care providers.

Supports Heart Health & Energy Metabolism*

U.S. LAB POTENCY TESTED

Smart Facts Niacin, also known as Vitamin B-3, supports heart health, energy metabolism and nervous system health.* Niacin also helps maintain healthy cell growth and metabolic function.* This product is formulated to release Niacin over a prolonged period of time.

STORE AT ROOM TEMPERATURE AND AVOID EXCESSIVE HEAT.

{Wheat} FREE OF Gluten & Wheat

GUARANTEED LABORATORY TESTED QUALITY

{Bottle} PLEASE RECYCLE

Prod. No. 48695 06E B5800 EAB

Metadata

Product Details

UPC / SKU0 30768 03993 6
DSLD Entry Date2014-02-26
Product TypeVitamin
FormCapsule
DSLD ID30636
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.