🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 83% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Capsule(s) Serving Size
Botanical with Nutrients Product Type
83% Evidence Coverage

Supplement Facts — Evidence Check

5 mg (25% DV)
✅ Within RDA (0.4× RDA of 14 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 5mg UL 35mg
5 mg (250% DV)
📊 3.8× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 5mg UL 100mg
Calcium
37 mg (4% DV)
25 mg (6% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 25mg
📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)
This product: 100mg
50 mg
📊 Market median: 300.0mg (214 products) 📚 23 studies (Tier A: 0, B: 6)
This product: 50mg

Other Ingredients

Dicalcium Phosphate Gelatin Silica Vegetable Magnesium Stearate

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (78% of products) Nutrient (52% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Directions: For adults, take one (1) capsule twice daily as needed or before bedtime. As a reminder, discuss the supplements and medications you take with your health care providers.

⚠️ Warnings & Precautions

As a reminder, discuss the supplements and medications you take with your health care providers.

Keep out of reach of children.

Tamper Resistant: Do not use if seal under cap is broken or missing.

Warning: Not for use by pregnant or lactating women. Avoid this product if you have heart problems or are taking antidepressants or weight-control drugs.

May Cause Drowsiness: Do not drive a motor vehicle or operate heavy machinery while using this product.

Consult your doctor before use if you have, or have had, any health condition or if you are taking any medications or remedies, including OTC medications, or are planning any medical procedure.

Discontinue use and consult your doctor if any adverse reactions occur, such as gastrointestinal discomfort, or headache.

Not intended for use by persons under the age of 18.

🧪 Formulation Notes

L-5-Hydroxytryptophan

This formula also includes B vitamins to promote nervous system health and the herb Valerian.

Additional Information

PROD. NO. 5315 B5316 02B

Supports Nervous System Health

Store in a dry place and avoid excessive heat.

Good Manufacturing Practices GMP

5-HTP is a precursor to serotonin, a neurotransmitter involved in sending messages through the nervous system.

Actual size

Product Details

UPC / SKU 0 17339 05315 7
DSLD Entry Date 2011-12-23
Product Type Botanical with Nutrients
Form Capsule
Brand Radiance
DSLD ID 3057
Data Updated 2026-04-11

Research Evidence

21 Research Sources
53 Avg Quality Score
11 Systematic Review
6 Rct
4 Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025
View all evidence for 5 Htp →

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