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5-HTP 100 mg

product on market Capsule Radiance Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 83% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

5-HTP is supported by moderate evidence for mood regulation, while B6 and magnesium act as essential cofactors in neurotransmitter synthesis. Niacin and calcium provide general metabolic and physiological support. Overall, the ingredient profile is backed by a mix of strong and moderate research evidence.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP 100 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
Botanical with Nutrients
Product Type
83%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

5 mg (25% DV)
Within RDA (0.4× RDA) 196 studies (A:5, B:63)
5 mg (250% DV)
3.8× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
Calcium
37 mg (4% DV)
25 mg (6% DV)
Within RDA (0.1× RDA) 316 studies (A:8, B:159)
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)
50 mg
Market median: 300.0mg (214 products) 25 studies (A:0, B:6)

Other Ingredients

Dicalcium Phosphate Gelatin Silica Vegetable Magnesium Stearate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: For adults, take one (1) capsule twice daily as needed or before bedtime. As a reminder, discuss the supplements and medications you take with your health care providers.

Warnings & Precautions

As a reminder, discuss the supplements and medications you take with your health care providers.

Keep out of reach of children.

Tamper Resistant: Do not use if seal under cap is broken or missing.

Warning: Not for use by pregnant or lactating women. Avoid this product if you have heart problems or are taking antidepressants or weight-control drugs.

May Cause Drowsiness: Do not drive a motor vehicle or operate heavy machinery while using this product.

Consult your doctor before use if you have, or have had, any health condition or if you are taking any medications or remedies, including OTC medications, or are planning any medical procedure.

Discontinue use and consult your doctor if any adverse reactions occur, such as gastrointestinal discomfort, or headache.

Not intended for use by persons under the age of 18.

Formulation Notes

L-5-Hydroxytryptophan

This formula also includes B vitamins to promote nervous system health and the herb Valerian.

Additional Information

PROD. NO. 5315 B5316 02B

Supports Nervous System Health

Store in a dry place and avoid excessive heat.

Good Manufacturing Practices GMP

5-HTP is a precursor to serotonin, a neurotransmitter involved in sending messages through the nervous system.

Actual size

Metadata

Product Details

UPC / SKU0 17339 05315 7
DSLD Entry Date2011-12-23
Product TypeBotanical with Nutrients
FormCapsule
DSLD ID3057
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.