ACV Keto Gummies 1000 mg by Simpli Health

96/100

This product looks safe

Folate: 400mg is 400.0× the Tolerable Upper Intake Level (1.0mg)
33% of ingredients have research evidence

C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

The ingredient profile primarily consists of basic macronutrients and folate, which supports cellular function and DNA synthesis. There is strong evidence for the role of folate in metabolic health, though the overall evidence coverage for this specific formulation is very limited. The product maintains a high safety score with no significant concerns noted.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 400mg is 400.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Open Full PDF View on NIH DSLD →

Details

Label Data

2 Gummy(ies)

Serving Size

Servings

Botanical with Nutrients

Product Type

33%

Evidence Coverage

Ingredients

Supplement Facts — Evidence Check

Calories

24 Calorie(s)

Total Carbohydrate

6 Gram(s) (2% DV)

Sodium

12 mg (1% DV)

Total Sugars

4 Gram(s) (8% DV)

Folate

400 mcg DFE (100% DV)

Exceeds UL by 400.0× (UL: 1.0 mg) 226 studies (A:10, B:105)

Vitamin B12

2 mcg (83% DV)

Within RDA (0.8× RDA) 139 studies (A:1, B:44)

Apple Cider Vinegar

1000 mg

Pomegranate Fruit Juice, Powder

80 mcg

Market median: 250.0mg (182 products) 10 studies (A:0, B:2)

Beet Root Juice, Powder

80 mcg

Other Ingredients

Glucose Syrup Sugar Glucose Pectin Sodium Citrate Citric Acid Apple Flavor, Natural Caranauba Wax Purple Carrot Juice Concentrate Beta-Carotene

Claims

Label Claims — Verification

Unverified Nutrient

Unverified All Other

Unverified Structure/Function

Info

Product Information

Directions for Use

Suggested Use: As a dietary supplement take 2 gummies daily, or as directed by a healthcare professional.

Warnings & Precautions

Warning: for healthy individuals 18 years and older. Keep out of reach of children.

Consult a healthcare professional prior to use if you are pregnant or nursing, taking medication, or have a medical condition.

Do not exceed recommended dose. Do not use if safety seal is broken or missing.

Formulation Notes

Advanced maximum strength ketosis formula Max strength

Formulated with: Apple cider vinegar, beet root juice, B6, B12

Additional Information

Notice: Store in a cool, dry place.

Metadata

Product Details

DSLD Entry Date2024-03-22

Product TypeBotanical with Nutrients

FormGummy or Jelly

BrandSimpli Health

DSLD ID304612

Data Updated2026-04-11

Research

Research Evidence

363

Research Sources

Avg Quality

187

Meta Analysis

Systematic Review

Rct

Guideline

Clinical Trial

Cochrane Review

Regulatory Source

Other

Openfda Safety

A Homocysteine-lowering interventions for preventing cardiovascular events

Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI

A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes

Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI

A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies

Meta Analysis Digestive diseases and sciences 2021 PubMed DOI

A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis

Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI

A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Meta Analysis Nutrients 2024 PubMed DOI

A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis

Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI

A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies

Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI

A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials

Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI

A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants

Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI

A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care

Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI

View all evidence for Folate →

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Folate research Best Folate All Folate products More from Simpli Health View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.