Home/ Supplements/ Folate/ 5-MTHF Plus B12 Natural Cherry Flavor

5-MTHF Plus B12 Natural Cherry Flavor

product on market Tablet or Pill XYMOGEN Safety: 80/100
80/100

This product is generally safe

  • Folate: 1700mg is 1700.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Folate and Vitamin B12 are essential nutrients that support methylation, cognitive function, and red blood cell formation. There is strong clinical evidence supporting their roles in neurological health and homocysteine regulation. This combination is generally well-tolerated and maintains a high safety profile for most users.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 1700mg is 1700.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for 5-MTHF Plus B12 Natural Cherry Flavor
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Quick Dissolve Tablet(s)
Serving Size
30
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1700 mcg DFE (425% DV)
Exceeds UL by 1700.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
2500 mcg (104167% DV)
1041.7× RDA — above typical dose 139 studies (A:1, B:44)

Other Ingredients

Xylitol Ascorbyl Palmitate Silica Cherry Flavor, Natural
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take one cherry-flavored tablet daily, or use as directed by your healthcare professional.

Warnings & Precautions

Consult your healthcare professional prior to use.

Individuals taking medication should discuss potential interactions with their healthcare professional.

Do not use if tamper seal is damaged.

Storage: Keep closed in a cool, dry place out of reach of children.

Formulation Notes

5-MTHF Plus B12 features Quatrefolic and methylcobalamin in great-tasting, quick-dissolve tablet form. Quatrefolic is the glucosamine salt of 5-MTHF-the most biologically active form of folate that increases plasma folate more effectively than folic acid

Formulated to exclude: Wheat, gluten, yeast, soy protein, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.

Biologically Active Folate and B12

Additional Information

Storage: Keep closed in a cool, dry place out of reach of children.

ePV (ePedigree Verification)

Third-Party Verified GMP Compliant

Scan this code to learn more! This package is completely recyclable

Metadata

Product Details

UPC / SKU8 71149 00422 4
DSLD Entry Date2023-12-14
Product TypeVitamin
FormTablet or Pill
BrandXYMOGEN
DSLD ID303624
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
View all evidence for Folate →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.