5-MTHF ES
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- Folate: 17000mg is 17000.0× the Tolerable Upper Intake Level (1.0mg)
- 100% of ingredients have research evidence
What the Evidence Says
AI-generated · Qwen 3.6 · grounded in 1 source · methodologyFolate is essential for DNA synthesis and cellular methylation, with strong evidence supporting its role in supporting cardiovascular and neurological health. However, the limited evidence coverage for this specific formulation and a safety score of 60 suggest potential concerns regarding suitability for all users. Consult a professional to ensure appropriate dosing.
AI-generated summary based on research evidence. Not medical advice.
Safety Alerts
Folate: 17000mg is 17000.0× the Tolerable Upper Intake Level (1.0mg)
This product received a low safety score because the amount of folate provided significantly exceeds the recommended upper intake level. This means the dosage is much higher than what is generally considered safe for daily consumption.
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Product Information
Directions for Use
Directions: Take one to two capsules daily, or as directed by your healthcare professional.
Warnings & Precautions
Consult your healthcare professional prior to use.
Individuals taking medication should discuss potential interactions with their healthcare professional.
Do not use if tamper seal is damaged.
Storage: Keep closed in a cool, dry place out of reach of children.
Formulation Notes
5-MTHF ES provides 17,000 mcg DFE of 5-MTHF (5-methyltetrahydrofolate) per serving. 5-MTHF is the most biologically active form of the water-soluble B vitamin, folate; and it may be the preferred form for those with variations in digestion, absorption, or folate metabolism. Data suggest that in comparison to synthetic folic acid, 5-MTHF increases plasma folate more effectively. In this formula, 5-MTHF is provided as Quatrefolic - the glucosamine salt of 5-MTHF. Quatrefolic has demonstrated greater stability, solubility, and bioavailability when compared to calcium salt forms of 5-MTHF.
Formulated to exclude: Wheat, gluten, corn, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners and artificial preservatives.
Vegetarian caps
Bioactive Folate as Quatrefolic
Additional Information
Storage: Keep closed in a cool, dry place out of reach of children.
Vegetarian caps
ePV (ePedigree Verification) Third-Party Verified GMP Compliant
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.