Home/ Supplements/ Niacin/ Niacin 500 mg Time Released

Niacin 500 mg Time Released

product on market Other (e.g. tea bag) Sundown Naturals Safety: 80/100
80/100

This product is generally safe

  • Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)
  • 50% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

Niacin is supported by strong evidence for its role in lipid management and cellular energy production. Calcium serves as a common stabilizer in time-release formulations to regulate nutrient delivery. Overall, clinical evidence coverage for this specific combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for Niacin 500 mg Time Released
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Caplet(s)
Serving Size
Single Vitamin and Mineral
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

500 mg (2500% DV)
Exceeds UL by 14.3× (UL: 35 mg) 196 studies (A:5, B:63)
Calcium
106 mg (11% DV)

Other Ingredients

Vegetable Cellulose Stearic Acid Vegetable Magnesium Stearate
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

DIRECTIONS: FOR ADULTS, TAKE ONE (1) CAPLET DAILY, PREFERABLY WITH A MEAL.

Do not take on an empty stomach. Do not take more than the recommended dose unless prescribed by your doctor.

Warnings & Precautions

Discontinue use and consult your doctor if any adverse reactions occur.

KEEP OUT OF REACH OF CHILDREN.

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

WARNING: Not intended for use by pregnant or nursing women. If you are taking any medications or have any medical condition, consult your doctor before use.

NOTICE: Use of this product may cause a temporary skin flushing (hot feeling and skin redness), burning, itching, or rash caused by an increase in blood flow near the skin. Sensitive individuals may experience unexpected drop of blood pressure or dizziness.

Formulation Notes

No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Starch, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.

VEGETARIAN FORMULA

Additional Information

As a reminder, discuss the supplements and medications you take with your health care providers.

Smart Facts Niacin, also known as Vitamin B-3, supports heart health, energy metabolism and nervous system health.* Niacin also helps maintain healthy functions of the skin.* This product is formulated to release Niacin over a prolonged period of time.

STORE AT ROOM TEMPERATURE AND AVOID EXCESSIVE HEAT.

{Bottle} PLEASE RECYCLE

{Wheat} FREE OF Gluten & Wheat

GUARANTEED LABORATORY TESTED QUALITY

Prod. No. 44761 11G B47060 GAC

Supports Heart Health & Energy Metabolism*

Metadata

Product Details

UPC / SKU0 30768 60748 7
DSLD Entry Date2014-02-26
Product TypeSingle Vitamin and Mineral
FormOther (e.g. tea bag)
DSLD ID30310
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.