🟢 94/100

This product looks safe

  • Manganese: 40mg is 3.6× the Tolerable Upper Intake Level (11mg)
  • Manganese: 20mg is 1.8× the Tolerable Upper Intake Level (11mg)
  • 25% of ingredients have research evidence
D Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Manganese: 40mg is 3.6× the Tolerable Upper Intake Level (11mg)
⚠️ Manganese: 20mg is 1.8× the Tolerable Upper Intake Level (11mg)

Label Data

29.57 mL Serving Size
15 Servings
Other Combinations Product Type
25% Evidence Coverage

Supplement Facts — Evidence Check

Calories
30 Calorie(s)
Total Carbohydrate
7 Gram(s) (3% DV)
Iron
12 mg (67% DV)
40 mg (1733% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 3.6× (UL: 11 mg) 📚 8 studies — no high-quality reviews
RDA 2.3mg This product: 40mg UL 11mg
20 mg (870% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1.8× (UL: 11 mg) 📚 8 studies — no high-quality reviews
RDA 2.3mg This product: 20mg UL 11mg
1000 mg
📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)
This product: 1000mg
800 mg
📊 Market median: 600.0mg (79 products) 📚 24 studies (Tier A: 0, B: 6)
This product: 800mg
📊 Market median: 20.0mg (931 products) 📚 233 studies (Tier A: 1, B: 90)
This product: 750mg
OptiMSM
500 mg
Micronized SierraSil
375 mg
Black Cherry
200 mg
Black Cherry
100 mg

Other Ingredients

Water, Purified Fructose Natural Honey Citric Acid Oligofructose EFAC Blend Natural Flavors Xanthan Gum Natural color Potassium Sorbate Sodium Benzoate Luo Han Guo Pea Protein

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (89% of products) Nutrient (16% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: Shake Well. As a dietary supplement, take two tablespoons or one capful (29.57 mL) daily with a meal. For extra-strength results, take twice daily. May be mixed with water or juice.

Recommended Usage Guidelines: If you weigh less than 120 lbs (54kg): Take 1 oz. (30 ml) = 1000 mg Glucosamine, 800 mg Chondroitin, 500 mg MSM and 375 mg SierraSil If you weigh 120-200 lbs (54-91 kg) Take 1½ oz (45 ml) = 1500 mg Glucosamine, 1200 mg Chondroitin, 750 mg MSM and 563 mg SierraSil If you weigh more than 200 lbs (91kg) Take 2 oz (60 ml) = 2000 mg Glucosamine, 1600 mg Chondroitin, 1000 mg MSM and 750 mg SierraSil

⚠️ Warnings & Precautions

Warning: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately.

This is not a prescription product. It is a dietary supplement made with the highest possible standards.

🧪 Formulation Notes

Nutritional support for healthy joint function Advanced therapeutics

Advanced Therapeutics Glucosamine Chondroitin MSM with Collagen Ultra Rx-Joint Liquid provides powerful and effective joint support for unmatched results! Discover the proven benefits of glucosamine, chondroitin, MSM and collagen, enhanced with the cutting-edge support of micronized SierraSil, black cherry and a proprietary blend of esterified fatty acid carbons (EFAC), Including cetyl-myristolate. These outstanding nutrients comprise a unique formulation that provides unparalleled nutritional support for peak joint lubrication and mobility. Nourish your quality natural nutrition you deserve. Triple strength ultra RX-joint liquid only from natures plus!

Free from artificial colors and artificial sweeteners. Free from the allergens milk, eggs, tree nuts, peanuts, wheat and soy.

Delicious mixed berry flavor with other natural flavors Black cherry Seirrasil

Gluten free

OptiMSM Micronized SierraSil Nature's ultimate Mineral

The iron in SierraSil is naturally occurring and has been shown to be safe for human consumption. Studies show that only 1.2 mg or 7% Daily Value is bioaccessible.

Additional Information

Keep tightly closed. Refrigerate after opening.

Servings per container 30, Extra-Strength Servings per container 15

Product Details

UPC / SKU 0 97467 49291 2
DSLD Entry Date 2023-10-24
Product Type Other Combinations
Form Liquid
Brand NaturesPlus
DSLD ID 298223
Data Updated 2026-04-11

Research Evidence

39 Research Sources
50 Avg Quality Score
20 Rct
9 Meta Analysis
4 Clinical Trial
3 Systematic Review
1 Regulatory Source
1 Openfda Safety
B Interventions for the management of temporomandibular joint osteoarthritis
Systematic Review The Cochrane database of systematic reviews 2012
B Glucosamine therapy for treating osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2005
B Chondroitin for osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2015
B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis
Meta Analysis Archives of orthopaedic and trauma surgery 2023
B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
Rct The New England journal of medicine 2006
B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review
Systematic Review International journal of molecular sciences 2023
B Scientific Opinion on glucosamine and joint health
Regulatory Source EFSA Journal 2009
B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis
Meta Analysis Computational and mathematical methods in medicine 2022
B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Rct Annals of the rheumatic diseases 2016
B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials
Meta Analysis Journal of orthopaedic surgery and research 2018
View all evidence for Glucosamine →

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