Phyto Methylate

product on market Capsule Premier Research Labs 🟢 Safety: 92/100
Brand: Premier Research Labs
🟢 92/100

This product looks safe

  • Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)
  • 80% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

2 Capsule(s) Serving Size
30 Servings
Botanical with Nutrients Product Type
80% Evidence Coverage

Supplement Facts — Evidence Check

25 mg (1470% DV)
📊 19.2× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 25mg UL 100mg
680 mcg DFE (170% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 680.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 680mg UL 1.0mg
1000 mcg (41667% DV)
📊 416.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 1.0mg
110 mg (20% DV)
✅ Within RDA (0.2× RDA of 550 mg) 📚 36 studies (Tier A: 1, B: 7)
RDA 550mg This product: 110mg UL 3500mg
Green Methyl Support
558 mg

Other Ingredients

Cellulose Water

Label Claims — Verification

❓ Nutrient
❓ All Other
❓ Structure/Function
All Other (98% of products) Structure/Function (89% of products) Nutrient (43% of products)

Target Groups

Adult (18 - 50 Years) Kosher

Product Information

📋 Directions for Use

Suggested use: Take 2 capsules daily or as directed by a health professional.

⚠️ Warnings & Precautions

Tamper seal: Use only if seal is intact.

Consult your health care practitioner if you are pregnant or nursing, taking medications or have a medical condition, before taking this or any other product.

Keep out of reach of children.

California Residents Only Prop 65 Warning Reproductive Harm www.P65Warnings.ca.gov

🧪 Formulation Notes

Supports healthy methylation, neurological, cardiovascular and emotional health

Contains activated folate (5-MTHF), activated B vitamins (vitamin B12 as methylcobalamin; vitamin B6 as P-5-P) and natural-source choline (from grape fermentation) Choline supports synthesis of acetylcholine, a key neurotransmitter, which supports cell membrane health as well as fat and cholesterol metabolism

Activated B vitamins, folate (5-MTHF) & choline

PRL's quality guarantee Purity verified Identity verified Potency verified FDA-Monitored cGMP Facility

Activated vitamin B forms

Tested for adulterants No radiation sterilization Pathogen tested by microbiology Heavy metal tested

OU (Kosher)

Advanced methylation, neurological & cardiovascular support

Additional Information

We are proud to offer many OU Kosher Certified products.

OU (Kosher)

Store in a cool, dry place.

Product Details

UPC / SKU 8 07735 02086 6
DSLD Entry Date 2023-10-24
Product Type Botanical with Nutrients
Form Capsule
Brand Premier Research Labs
DSLD ID 297560
Data Updated 2026-04-11

Research Evidence

153 Research Sources
55 Avg Quality Score
71 Systematic Review
51 Meta Analysis
19 Rct
6 Clinical Trial
2 Other
2 Regulatory Source
1 Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013
PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009
PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
PubMed DOI Cochrane
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021
PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016
PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020
PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006
PubMed Cochrane
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022
PubMed DOI
View all evidence for Vitamin B6 →

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