Home/ Supplements/ Vitamin B6/ Phyto Methylate

Phyto Methylate

product on market Capsule Premier Research Labs Safety: 92/100
92/100

This product looks safe

  • Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)
  • 80% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula provides B vitamins and choline, which are essential for methylation and neurological function. While research supporting these individual nutrients is strong, evidence coverage for this specific blend is limited. The profile maintains a high safety score for general consumption.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Phyto Methylate
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
30
Servings
Botanical with Nutrients
Product Type
80%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

25 mg (1470% DV)
19.2× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
680 mcg DFE (170% DV)
Exceeds UL by 680.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
1000 mcg (41667% DV)
416.7× RDA — above typical dose 139 studies (A:1, B:44)
110 mg (20% DV)
Within RDA (0.2× RDA) 38 studies (A:1, B:7)
Green Methyl Support
558 mg

Other Ingredients

Cellulose Water
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: Take 2 capsules daily or as directed by a health professional.

Warnings & Precautions

Tamper seal: Use only if seal is intact.

Consult your health care practitioner if you are pregnant or nursing, taking medications or have a medical condition, before taking this or any other product.

Keep out of reach of children.

California Residents Only Prop 65 Warning Reproductive Harm www.P65Warnings.ca.gov

Formulation Notes

Supports healthy methylation, neurological, cardiovascular and emotional health

Contains activated folate (5-MTHF), activated B vitamins (vitamin B12 as methylcobalamin; vitamin B6 as P-5-P) and natural-source choline (from grape fermentation) Choline supports synthesis of acetylcholine, a key neurotransmitter, which supports cell membrane health as well as fat and cholesterol metabolism

Activated B vitamins, folate (5-MTHF) & choline

PRL's quality guarantee Purity verified Identity verified Potency verified FDA-Monitored cGMP Facility

Activated vitamin B forms

Tested for adulterants No radiation sterilization Pathogen tested by microbiology Heavy metal tested

OU (Kosher)

Advanced methylation, neurological & cardiovascular support

Additional Information

We are proud to offer many OU Kosher Certified products.

OU (Kosher)

Store in a cool, dry place.

Metadata

Product Details

UPC / SKU8 07735 02086 6
DSLD Entry Date2023-10-24
Product TypeBotanical with Nutrients
FormCapsule
BrandPremier Research Labs
DSLD ID297560
Data Updated2026-04-11
Research

Research Evidence

153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016 PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020 PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 PubMed DOI
View all evidence for Vitamin B6 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.