TMG (Trimethylglycine) with Folic Acid & B-12 Powder
87/100
This product is generally safe
- Folate: 666mg is 666.0× the Tolerable Upper Intake Level (1.0mg)
- 67% of ingredients have research evidence
C
Label Compliance Grade
Product Label
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Safety Alerts
⚠️ Folate: 666mg is 666.0× the Tolerable Upper Intake Level (1.0mg)
Label Data
1.7 Gram(s)
Serving Size
133
Servings
Other Combinations
Product Type
67%
Evidence Coverage
Supplement Facts — Evidence Check
666 mcg DFE
(167% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 666.0× (UL: 1.0 mg)
📚 225 studies (Tier A: 10, B: 105)
6 mcg
(250% DV)
✅ 2.5× RDA — within safe limits
📚 138 studies (Tier A: 1, B: 44)
1000 mg
📊 Market median: 496.0mg (192 products)
📚 20 studies — no high-quality reviews
Other Ingredients
Mannitol
Natural Tropical Punch Flavor
Citric Acid
Silicon Dioxide
Stevia leaf extract
Label Claims — Verification
❓
All Other
All Other (100% of products)
Structure/Function (82% of products)
Nutrient (8% of products)
Target Groups
Adult (18 - 50 Years)
Gluten Free
Dairy Free
Product Information
📋 Directions for Use
Suggested Use: 1/3 teaspoon daily or as directed by your physician.
⚠️ Warnings & Precautions
Keep out of the reach of children.
🧪 Formulation Notes
Free of: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat or soy.
Gluten-free
Additional Information
Important: Store in a cool dry place and tightly capped.
Ultra Tested cGMP
503.694.1600
Product Details
Research Evidence
23
Research Sources
47
Avg Quality Score
18
Rct
3
Systematic Review
1
Meta Analysis
1
Clinical Trial
B
Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine
C
Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial
C
Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines
C
Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial
C
Association of Betaine-Homocysteine S-Methyl Transferase (rs3797546 and rs3733890) polymorphisms with non-syndromic cleft lip/palate: A meta-analysis
C
Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.
C
Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.
C
Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.
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