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5-MTHF 5 mg

product on market Capsule Kirkman Safety: 60/100
60/100

Review before taking

  • Folate: 8.33mg is 8.3× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

5-MTHF is a bioactive form of folate used to support methylation processes and homocysteine levels, with strong evidence for its role in cellular function. Due to a safety score of 60, users should be aware of potential adverse effects or contraindications. The overall evidence coverage for this specific profile remains limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 8.33mg is 8.3× the Tolerable Upper Intake Level (1.0mg)

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product received a low safety score because it contains 8.33mg of folate, which is over eight times the recommended maximum daily limit.

Label

Product Label

Label for 5-MTHF 5 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
60
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

8.33 mg DFE (2083% DV)
Exceeds UL by 8.3× (UL: 1.0 mg) 226 studies (A:10, B:105)

Other Ingredients

Microcrystalline Cellulose Hypromellose Water
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Info

Product Information

Directions for Use

Suggested use: One capsule daily or as directed by a physician.

Warnings & Precautions

Keep out of the reach of children.

Formulation Notes

Free of: Milk, eggs, fish, shellfish, tree nut, peanuts, wheat or soy

Hypoallergenic

Gluten-free

Methyltetrahydrofolate

Additional Information

Important: Store in a cool dry place and tightly capped.

Ultra Tested cGMP current Good Manufacturing Practices Consistent Quality

503.694.1600

Metadata

Product Details

UPC / SKU8 12325 02362 2
DSLD Entry Date2023-09-25
Product TypeVitamin
FormCapsule
BrandKirkman
DSLD ID296908
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.