SAM-e by Nature's Craft — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Capsule(s) Serving Size

90 Servings

Non-Nutrient/Non-Botanical Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

SAMe

150 mg

📊 Market median: 200.0mg (52 products) 📚 10 studies (Tier A: 0, B: 6)

This product: 150mg

Other Ingredients

Hypromellose Rice Flour Magnesium Stearate Hydroxypropyl Methylcellulose Propylene Glycol Triacetin Methacrylic Acid Copolymer

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating)

Product Information

📋 Directions for Use

Suggested Use: For adults, take one (1) capsule once or twice daily before a meal, or as directed by your physician. Do not take more than two (2) servings per day.

⚠️ Warnings & Precautions

Caution: Do not exceed recommended dose.

Not intended for pregnant or nursing mothers.

Not intended for children under 18 years of age.

If you are taking medications (especially antidepressants), have a known medical condition, or are planning to have a medical procedure, consult your doctor before use.

If you are taking medications (especially antidepressants), have a known medical condition, or are planning to have a medical procedure, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Individuals with bipolar disorder and manic depression should avoid this supplement.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

🧪 Formulation Notes

S-Adenosyl methionine

Better sleep Joint support Mood enhancement Cognition & memory Sleep & mood

Additional Information

Store in a cool, dry place.

Follow us on: Twitter, Facebook, Instagram bynaturescraft New look same craft

Made in the USA with global ingredients 3rd party lab verified Sourced from a GMP certified facility

Please recycle.

Product Details

DSLD Entry Date 2023-08-23

Product Type Non-Nutrient/Non-Botanical

Form Capsule

Brand Nature's Craft

DSLD ID 296722

Data Updated 2026-04-11

Research Evidence

12 Research Sources

58 Avg Quality Score

8 Meta Analysis

3 Systematic Review

1 Rct

B S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2006

PubMed

B S-adenosyl methionine (SAMe) for depression in adults

Meta Analysis The Cochrane database of systematic reviews 2016

PubMed

B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease

Meta Analysis Annals of the rheumatic diseases 2024

PubMed DOI

B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis

Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024

PubMed DOI

B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis

Meta Analysis General hospital psychiatry 2024

PubMed DOI

B S-adenosyl-L-methionine for alcoholic liver diseases

Systematic Review The Cochrane database of systematic reviews 2001

PubMed

B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis