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SAM-e

product on market Capsule Nature's Craft Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

SAMe is used to support mood regulation and joint health. Research providing evidence for these effects is generally considered moderate, though clinical data varies across different conditions. The ingredient profile maintains a high safety rating for most healthy adults.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for SAM-e
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
90
Servings
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

150 mg
Market median: 200.0mg (52 products) 12 studies (A:0, B:6)

Other Ingredients

Hypromellose Rice Flour Magnesium Stearate Hydroxypropyl Methylcellulose Propylene Glycol Triacetin Methacrylic Acid Copolymer
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: For adults, take one (1) capsule once or twice daily before a meal, or as directed by your physician. Do not take more than two (2) servings per day.

Warnings & Precautions

Caution: Do not exceed recommended dose.

Not intended for pregnant or nursing mothers.

Not intended for children under 18 years of age.

If you are taking medications (especially antidepressants), have a known medical condition, or are planning to have a medical procedure, consult your doctor before use.

If you are taking medications (especially antidepressants), have a known medical condition, or are planning to have a medical procedure, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Individuals with bipolar disorder and manic depression should avoid this supplement.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Formulation Notes

S-Adenosyl methionine

Better sleep Joint support Mood enhancement Cognition & memory Sleep & mood

Additional Information

Store in a cool, dry place.

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Made in the USA with global ingredients 3rd party lab verified Sourced from a GMP certified facility

Please recycle.

Metadata

Product Details

DSLD Entry Date2023-08-23
Product TypeNon-Nutrient/Non-Botanical
FormCapsule
BrandNature's Craft
DSLD ID296722
Data Updated2026-04-11
Research

Research Evidence

12
Research Sources
58
Avg Quality
8
Meta Analysis
3
Systematic Review
1
Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024 PubMed DOI
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024 PubMed DOI
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024 PubMed DOI
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015 PubMed DOI
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024 PubMed DOI
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.