Home/ Supplements/ Folate/ Intrinsi B12-Folate

Intrinsi B12-Folate

product on market Tablet or Pill Metagenics Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 33% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Metafolin and Vitamin B12 provide essential support for methylation and neurological function, with strong evidence supporting their role in homocysteine regulation. Intrinsic factor is utilized to facilitate the absorption of B12 in the gastrointestinal tract. Overall evidence coverage for this specific combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Intrinsi B12-Folate
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
60
Servings
Other Combinations
Product Type
33%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Metafolin
1330 mcg DFE (333% DV)
500 mcg (20833% DV)
208.3× RDA — above typical dose 139 studies (A:1, B:44)
Intrinsic Factor
20 mg

Other Ingredients

Microcrystalline Cellulose Cellulose Stearic Acid Croscarmellose Sodium
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take one tablet daily or as directed by your healthcare practitioner.

Warnings & Precautions

Caution: Keep out of the reach of children.

Practitioner exclusive

Formulation Notes

Intrinsi B12-Folate features vitamin B12 and folate in combination with intrinsic factor for enhanced absorption and utilization. These nutrients are important for healthy nervous system function and cardiovascular health.

This product is non-GMO and gluten-free.

Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)

Intrinsi B12-Folate with 20 mg intrinsic factor

Additional Information

Storage: Keep tightly closed in a cool, dry place.

Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)

Metadata

Product Details

UPC / SKU7 55571 01950 9
DSLD Entry Date2023-08-23
Product TypeOther Combinations
FormTablet or Pill
BrandMetagenics
DSLD ID295755
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.