🟢 90/100

This product looks safe

  • Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)
  • 75% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

Vitamin B6, folate, and B12 provide strong evidence for reducing homocysteine levels by supporting methylation pathways. Trimethylglycine serves as an additional methyl donor to assist in this process. These ingredients are generally well-tolerated with a high safety profile.

AI-generated summary based on research evidence. Not medical advice.

Product Label

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Safety Alerts

⚠️ Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Capsule(s) Serving Size
60 Servings
Other Combinations Product Type
75% Evidence Coverage

Supplement Facts — Evidence Check

25 mg (1471% DV)
📊 19.2× RDA — above typical dose (UL: 100 mg) 📚 114 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 25mg UL 100mg
667 mcg DFE (167% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 667.0× (UL: 1.0 mg) 📚 226 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 667mg UL 1.0mg
200 mcg (8333% DV)
📊 83.3× RDA — above typical dose 📚 139 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.2mg
📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 500mg

Other Ingredients

Cellulose Water Plant Fiber Ascorbyl Palmitate

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (98% of products) Structure/Function (89% of products) Nutrient (43% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Recommendation: As a dietary supplement, take 1 capsule, 2 times daily, with meals.

⚠️ Warnings & Precautions

Warning: if you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

🧪 Formulation Notes

Certified Gluten-Free by the Gluten-Free Certification Organization, www.gluten.org

Homocysteine Factors with Metafolin L-5-MTHF: Supports healthy homocysteine metabolism

Gluten-free, Non-GMO & Hypoallergenic

Gluten-free, Non-GMO & Hypoallergenic

Natural color variations can occur. Product can range from off-white to yellow.

Additional Information

Refrigerate After Opening.

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity. Scan to learn about our hypoallergenic supplements

GFCO.org (Gluten-free Certification Organization)

Product Details

UPC / SKU 7 66298 00151 7
DSLD Entry Date 2023-07-18
Product Type Other Combinations
Form Capsule
DSLD ID 293972
Data Updated 2026-04-11

Research Evidence

153 Research Sources
55 Avg Quality Score
71 Systematic Review
51 Meta Analysis
19 Rct
6 Clinical Trial
2 Other
2 Regulatory Source
1 Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022
View all evidence for Vitamin B6 →

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DSLD ID: 293972 Fetched: 2026-04-11
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