🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

📸

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Label Data

1 Caplet(s) Serving Size
Non-Nutrient/Non-Botanical Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

UltraMel
5 mg

Other Ingredients

Microcrystalline Cellulose Citric Acid Hydroxypropyl Methylcellulose Corn Starch, Modified Talc Magnesium Stearate Silicon Dioxide Cellulose Gum Dextrose Titanium Dioxide Polyvinyl Alcohol Cellulose Blue 1 Lake Polyethylene Glycol Mica-based Pearlescent Pigment Glycerin Polysorbate 80

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (86% of products) Nutrient (7% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Suggested Usage: Adults, take 1 caplet 30 to 90 minutes before intended bedtime. Do not exceed 2 caplets nightly. Intended for occasional sleeplessness.

⚠️ Warnings & Precautions

Contains: Wheat

Warning: Consult a healthcare provider if you are experiencing long-term sleep difficulties, before use in children, before use in pregnant or lactating women, those with a medical condition, and those taking medication.

Warning: Consult a healthcare provider if you are experiencing long-term sleep difficulties, before use in children, before use in pregnant or lactating women, those with a medical condition, and those taking medication.

Do not drive or operate machinery when taking melatonin.

This product may be contraindicated for individuals taking corticosteroids.

Keep out of reach of children.

Do not use if blister is torn or ripped or if there is any other evidence of tampering.

Contains bioengineered food ingredient.

🧪 Formulation Notes

Trouble sleeping? As we age and lead busier lives, our bodies produce less melatonin, the key ingredient we need to fall asleep and stay asleep. REMfresh, made with 99% ultrapure UltraMel melatonin, helps support the body’s own natural levels of melatonin for up to 7 hours. The REMfresh advantage Only REMfresh has the breakthrough melatonin IPP (Ion-Powered Pump) technology that promotes continuous release and absorption, allowing you to sleep longer and wake up ready to conquer the day.

REMfresh Extra Strength has 5 mg of melatonin per serving compared to the 0.5 mg and 2 mg per serving REMfresh products.

Clinically tested 7 hour absorption Fall asleep faster Say asleep longer Improve sleep quality Wake up REfreshed

5 mg UltraMel Melatonin

Additional Information

REMfrest 7 hour absorption, known as the MESA-WAVE, has been shown in a clinical trial.

Store in a cool, dry place.

#1 Sleep Doctor recommended Among primary care physicians with a certification in sleep disorders who recommended a non-prescription sleep aid brand. IQVIA ProVoice 2020 survey.

Questions/comments: Call us toll free 1-866-554-7071 or visit www.REMfresh.com

REM Absorption Kinetics Trial (REMAKT) a pharmacokinetic trial of 5 mg REMfresh, is not a sleep study. Approved after peer review and then published in Primary Care Companion for CNS Disorders, 2019.

Individual results may vary.

Vista Color

Product Details

UPC / SKU 8 57150 00601 3
DSLD Entry Date 2023-08-24
Product Type Non-Nutrient/Non-Botanical
Form Other (e.g. tea bag)
Brand REMfresh
DSLD ID 289156
Data Updated 2026-04-11

Research Evidence

291 Research Sources
55 Avg Quality Score
129 Meta Analysis
93 Systematic Review
51 Rct
11 Clinical Trial
2 Other
2 Regulatory Source
1 Openfda Safety
A Interventions for preventing delirium in hospitalised non-ICU patients
Meta Analysis The Cochrane database of systematic reviews 2016
A Melatonin for preoperative and postoperative anxiety in adults
Meta Analysis The Cochrane database of systematic reviews 2020
A Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ open 2022
B Pharmacological interventions for prevention of weight gain in people with schizophrenia
Meta Analysis The Cochrane database of systematic reviews 2022
B Melatonin for pre- and postoperative anxiety in adults
Meta Analysis The Cochrane database of systematic reviews 2015
B Prevention of depression in adults with long-term physical conditions
Meta Analysis The Cochrane database of systematic reviews 2021
B Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis
Systematic Review Lancet (London, England) 2022
B Does melatonin administration reduce the incidence of postoperative delirium in adults? Systematic review and meta-analysis
Meta Analysis BMJ open 2023
B Second-generation antidepressants for preventing seasonal affective disorder in adults
Meta Analysis The Cochrane database of systematic reviews 2015
B Interventions for preventing type 2 diabetes in adults with mental disorders in low- and middle-income countries
Meta Analysis The Cochrane database of systematic reviews 2021
View all evidence for Melatonin →

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