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REMfresh Extra Strength Advanced Ion-Powered Melatonin

product on market Other (e.g. tea bag) REMfresh Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade
Label

Product Label

Label for REMfresh Extra Strength Advanced Ion-Powered Melatonin
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Caplet(s)
Serving Size
Non-Nutrient/Non-Botanical
Product Type
0%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

UltraMel
5 mg

Other Ingredients

Microcrystalline Cellulose Citric Acid Hydroxypropyl Methylcellulose Corn Starch, Modified Talc Magnesium Stearate Silicon Dioxide Cellulose Gum Dextrose Titanium Dioxide Polyvinyl Alcohol Cellulose Blue 1 Lake Polyethylene Glycol Mica-based Pearlescent Pigment Glycerin Polysorbate 80
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Usage: Adults, take 1 caplet 30 to 90 minutes before intended bedtime. Do not exceed 2 caplets nightly. Intended for occasional sleeplessness.

Warnings & Precautions

Contains: Wheat

Warning: Consult a healthcare provider if you are experiencing long-term sleep difficulties, before use in children, before use in pregnant or lactating women, those with a medical condition, and those taking medication.

Warning: Consult a healthcare provider if you are experiencing long-term sleep difficulties, before use in children, before use in pregnant or lactating women, those with a medical condition, and those taking medication.

Do not drive or operate machinery when taking melatonin.

This product may be contraindicated for individuals taking corticosteroids.

Keep out of reach of children.

Do not use if blister is torn or ripped or if there is any other evidence of tampering.

Contains bioengineered food ingredient.

Formulation Notes

Trouble sleeping? As we age and lead busier lives, our bodies produce less melatonin, the key ingredient we need to fall asleep and stay asleep. REMfresh, made with 99% ultrapure UltraMel melatonin, helps support the body’s own natural levels of melatonin for up to 7 hours. The REMfresh advantage Only REMfresh has the breakthrough melatonin IPP (Ion-Powered Pump) technology that promotes continuous release and absorption, allowing you to sleep longer and wake up ready to conquer the day.

REMfresh Extra Strength has 5 mg of melatonin per serving compared to the 0.5 mg and 2 mg per serving REMfresh products.

Clinically tested 7 hour absorption Fall asleep faster Say asleep longer Improve sleep quality Wake up REfreshed

5 mg UltraMel Melatonin

Additional Information

REMfrest 7 hour absorption, known as the MESA-WAVE, has been shown in a clinical trial.

Store in a cool, dry place.

#1 Sleep Doctor recommended Among primary care physicians with a certification in sleep disorders who recommended a non-prescription sleep aid brand. IQVIA ProVoice 2020 survey.

Questions/comments: Call us toll free 1-866-554-7071 or visit www.REMfresh.com

REM Absorption Kinetics Trial (REMAKT) a pharmacokinetic trial of 5 mg REMfresh, is not a sleep study. Approved after peer review and then published in Primary Care Companion for CNS Disorders, 2019.

Individual results may vary.

Vista Color

Metadata

Product Details

UPC / SKU8 57150 00601 3
DSLD Entry Date2023-08-24
Product TypeNon-Nutrient/Non-Botanical
FormOther (e.g. tea bag)
DSLD ID289156
Data Updated2026-04-11
Research

Research Evidence

291
Research Sources
55
Avg Quality
129
Meta Analysis
93
Systematic Review
51
Rct
11
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Interventions for preventing delirium in hospitalised non-ICU patients
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed DOI
A Melatonin for preoperative and postoperative anxiety in adults
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ open 2022 PubMed DOI
B Pharmacological interventions for prevention of weight gain in people with schizophrenia
Meta Analysis The Cochrane database of systematic reviews 2022 PubMed DOI
B Melatonin for pre- and postoperative anxiety in adults
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prevention of depression in adults with long-term physical conditions
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis
Systematic Review Lancet (London, England) 2022 PubMed DOI
B Does melatonin administration reduce the incidence of postoperative delirium in adults? Systematic review and meta-analysis
Meta Analysis BMJ open 2023 PubMed DOI
B Second-generation antidepressants for preventing seasonal affective disorder in adults
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Interventions for preventing type 2 diabetes in adults with mental disorders in low- and middle-income countries
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.