Home/ Supplements/ Vitamin B6/ Methyl-Guard

Methyl-Guard

product on market Capsule Thorne Safety: 90/100
90/100

This product looks safe

  • Folate: 2mg is 2.0× the Tolerable Upper Intake Level (1.0mg)
  • 75% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Vitamin B6, folate, and B12 provide strong evidence for supporting homocysteine metabolism and methylation processes. Betaine anhydrous further assists in these biochemical pathways. Overall, there is limited clinical evidence coverage for this specific combination, though the individual components are well-studied.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 2mg is 2.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Methyl-Guard
Open Full PDF View on NIH DSLD →
Details

Label Data

3 Capsule(s)
Serving Size
60
Servings
Other Combinations
Product Type
75%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

20.4 mg (1200% DV)
15.7× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
2 mg DFE (500% DV)
Exceeds UL by 2.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
1.2 mg (50000% DV)
500.0× RDA — above typical dose 139 studies (A:1, B:44)
1.8 Gram(s)
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews

Other Ingredients

Hypromellose Silicon Dioxide Calcium Citrate Calcium Laurate
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: Take 3 capsules two times daily or as recommended by your health-care practitioner.

Warnings & Precautions

Tamper evident: Use only if bottle is sealed.

If pregnant, consult your health-care practitioner before using this product.

Formulation Notes

Heart/Vessels Mood

Gluten free

Methylation Factors

This product uses Gnosis S.p.A.’s L-5-Methyltetrahydrofolic Acid, Glucosamine Salt (Quatrefolic).

Additional Information

Store tightly sealed in a cool, dry place.

Manufactured in the USA using US & imported ingredients

Metadata

Product Details

UPC / SKU6 93749 78703 7
DSLD Entry Date2023-05-24
Product TypeOther Combinations
FormCapsule
BrandThorne
DSLD ID284244
Data Updated2026-04-11
Research

Research Evidence

153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016 PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020 PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 PubMed DOI
View all evidence for Vitamin B6 →
Compare

Similar Products

Water Ease
Designs for Health · Capsule
100
Mag Aspartate
Karuna · Capsule
100
Vitamin B-6 50 mg
Kirkman · Capsule
100
Neuro-Balance 620 Milligrams
Montiff · Capsule
100
Vitamin B-6 50 Milligrams
NutraBio · Capsule
100
View all Vitamin B6 products →
Vitamin B6 research Best Vitamin B6 All Vitamin B6 products More from Thorne View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.