5-MTHF 5 mg
60/100
Review before taking
- Folate: 8.3mg is 8.3× the Tolerable Upper Intake Level (1.0mg)
- 100% of ingredients have research evidence
C
Label Compliance Grade
Product Label
Have a supplement label? Find it here.
Upload a photo of any supplement label to search our database of 92,312 products.
Safety Alerts
⚠️ Folate: 8.3mg is 8.3× the Tolerable Upper Intake Level (1.0mg)
This supplement contains a much higher amount of folate than the recommended maximum daily limit.
Label Data
1 Capsule(s)
Serving Size
60
Servings
Vitamin
Product Type
100%
Evidence Coverage
Supplement Facts — Evidence Check
8.3 mg DFE
(2075% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 8.3× (UL: 1.0 mg)
📚 225 studies (Tier A: 10, B: 105)
Other Ingredients
Microcrystalline Cellulose
Hypromellose
Leucine
Silicon Dioxide
Label Claims — Verification
❓
Nutrient
❓
All Other
❓
Structure/Function
All Other (99% of products)
Structure/Function (77% of products)
Nutrient (60% of products)
Approved Health (5% of products)
Target Groups
Adult (18 - 50 Years)
Gluten Free
Product Information
📋 Directions for Use
Suggested use: Take 1 capsule one to two times daily or as recommended by your health-care practitioner.
⚠️ Warnings & Precautions
Tamper evident: Use only if bottle is sealed.
If pregnant, consult your health-care practitioner before using this product.
🧪 Formulation Notes
Foundational Mood Heart/Vessels
Gluten free
Methylfolate
This product uses Gnosis S.p.A.'s L-5-Methyltetrahydrofolate (Extra-folate-S). Extrafolate-S is a registered trademark of Gnosis S.p.A.
Additional Information
Store tightly sealed in a cool, dry place.
Manufactured in the USA using US & imported ingredients
Product Details
Research Evidence
363
Research Sources
57
Avg Quality Score
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A
Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
A
Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
A
The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
A
A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
A
Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
A
Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
A
Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
A
Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Compare Similar Products
Bio-Plus Biotin With Folic Acid
Douglas Laboratories
100
Folic Acid
OL Olympian Labs
100
L-5-MTHF Natural S-Isomer
Designs for Health
100
Folic Acid
DaVinci Laboratories Of Vermont
100
SAMe with Vitamins B-6, B-12 and 5-MTHF
Designs for Health
100