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Total 5-HTP

product on market Tablet or Pill Nutri-West Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 60% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula combines 5-HTP and DL-Phenylalanine, which are precursors to serotonin and dopamine with moderate evidence for mood support. Melatonin and pregnenolone are included to assist with sleep and hormonal balance, though evidence for these specific combinations is limited. The profile is supported by Pyridoxal 5-Phosphate to facilitate neurotransmitter synthesis.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Total 5-HTP
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Other Combinations
Product Type
60%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

50 mg
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)
2.3× RDA — within safe limits 114 studies (A:3, B:35)
1 mg
Market median: 3.0mg (984 products) 240 studies (A:2, B:109)
DL-Phenylalanine
12 mg
Market median: 30.0mg (45 products)
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Directions for use: 1 tablet daily or as directed. CAUTION: DO NOT USE WITH MAO INHIBITOR OR SSRI DRUGS.

Warnings & Precautions

KEEP OUT OF REACH OF CHILDREN.

TAMPER RESISTANT OUTER SEAL DO NOT USE IF BROKEN.

CAUTION: DO NOT USE WITH MAO INHIBITOR OR SSRI DRUGS.

Formulation Notes

Contains no starch, salt, sugar, wheat, corn, yeast, milk, or preservatives.

Additional Information

FOR DISTRIBUTION BY HEALTH CARE PROFESSIONALS ONLY.

204035 MFG06/2012

"When You Want The Best"

Store in cool, dry place.

Manufactured under strict GMP and USP guidelines.

Product # 2727

Metadata

Product Details

DSLD Entry Date2013-12-24
Product TypeOther Combinations
FormTablet or Pill
BrandNutri-West
DSLD ID28290
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.