🟢 80/100

This product is generally safe

  • Nicotinamide Riboside Chloride: 200mg is 5.7× the Tolerable Upper Intake Level (35mg)
  • 50% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Nicotinamide Riboside Chloride: 200mg is 5.7× the Tolerable Upper Intake Level (35mg)

Label Data

2 Capsule(s) Serving Size
30 Servings
Botanical with Nutrients Product Type
50% Evidence Coverage

Supplement Facts — Evidence Check

⚠️ Exceeds Tolerable Upper Intake Level by 5.7× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 200mg UL 35mg
Schizandra Fruit Extarct, Powder
600 mg

Other Ingredients

Pullulan Polysaccharide Rice, Powder Bamboo Extract, Powder Rice Extract Blend

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (90% of products) Nutrient (28% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: Take 2 capsules, 1-2 times per day or as directed by a health care professional.

⚠️ Warnings & Precautions

Keep out of the reach of children.

🧪 Formulation Notes

NR (Nicotinamide Riboside) is made in the human body, but production declines dramatically as we age. NR is a precursor to NAD+, a vital molecule that supports metabolic functions as well as klotho and sirtuin production and expression, which in turn harmonize external and internal environment. QuintessenceNR is made with organically grown Schizandra berries from Changbai Mountain, Manchuria. Called "the quintessence of tonic herbs," it is traditionally believed to benefit all organs in the human body. This is the ultimate (quintessential) adaptogenic formulation.

Pullulan caps - 100% natural, water-soluble polysaccharide produced through a fermentation process; non-GMO; no starch, preservatives or chemical modifications; gluten free.

Pullulan caps - 100% natural, water-soluble polysaccharide produced through a fermentation process; non-GMO; no starch, preservatives or chemical modifications; gluten free.

Additional Information

Fire Wood Earth Water Metal

Di Tao Certified Authentic Source

QuintessenceNR 400 mg per capsule

Product Details

UPC / SKU 6 79372 00110 8
DSLD Entry Date 2022-11-22
Product Type Botanical with Nutrients
Form Capsule
DSLD ID 279198
Data Updated 2026-04-11

Research Evidence

10 Research Sources
49 Avg Quality Score
8 Rct
1 Systematic Review
1 Clinical Trial
B Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults
Rct Nature communications 2018
C The effects of NAD+ precursor (nicotinic acid and nicotinamide) supplementation on weight loss and related hormones: a systematic review and meta-regression analysis of randomized controlled trials
Systematic Review Frontiers in nutrition 2023
C Effect of nicotinamide riboside on airway inflammation in COPD: a randomized, placebo-controlled trial.
Rct Nature aging
C Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults
Rct Scientific reports 2019
C Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures
Rct Cell reports 2019
C Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin
Rct Aging cell 2023
C Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI
Rct BMC nephrology 2020
C Clinical Trial of Niagen to Examine Recovery in People With Persistent Cognitive and Physical Symptoms After COVID-19
Clinical Trial ClinicalTrials.gov 2021
C A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals.
Rct JCI insight
C Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double-Blind Randomized Crossover Placebo-Controlled Trial.
Rct Aging cell
View all evidence for Nicotinamide Riboside →

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