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MethylAssist

product on market Capsule Pure Encapsulations Safety: 90/100
90/100

This product looks safe

  • Folate: 1667mg is 1667.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Vitamin B6, folate, and B12 are supported by strong evidence for their roles in homocysteine metabolism and neurological function. Benfotiamine provides a fat-soluble derivative of B1 provides moderate evidence for supporting glucose metabolism. These ingredients generally maintain a high safety profile when taken within recommended dosages.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 1667mg is 1667.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for MethylAssist
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
90
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

16 mg (941% DV)
12.3× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
1667 mcg DFE (417% DV)
Exceeds UL by 1667.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
1000 mcg (41667% DV)
416.7× RDA — above typical dose 139 studies (A:1, B:44)
62.5× RDA — above typical dose 76 studies (A:0, B:33)

Other Ingredients

hypoallergenic Plant Fiber Vegetarian Capsule
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Recommendations: As a dietary supplement, take 1 capsule daily, with a meal, or as directed by a health professional.

Warnings & Precautions

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

Formulation Notes

Supports neurological, cardiovascular, and emotional health

Gluten-free, Non-GMO & Hypoallergenic

Gluten-free, Non-GMO & Hypoallergenic

Additional Information

Store in a cool, dry place.

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

GFCO.org Certified gluten-free by the gluten-free certification organization, www.gluten.org

Scan to learn about hypoallergenic supplements

Metadata

Product Details

UPC / SKU7 66298 11495 8
DSLD Entry Date2022-11-22
Product TypeVitamin
FormCapsule
DSLD ID277776
Data Updated2026-04-11
Research

Research Evidence

153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016 PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020 PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.