Home/ Supplements/ Folate/ L-5-MTHF SAP

L-5-MTHF SAP

product on market Capsule NFH Safety: 60/100
60/100

Review before taking

  • L-Methylfolate: 1700mg is 1700.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

L-Methylfolate is used to support folate levels and cognitive function, with moderate research evidence supporting its efficacy. Due to a safety score of 60, users should be aware of potential contraindications or adverse reactions. Consult a professional to ensure this ingredient is appropriate for your specific health profile.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

L-Methylfolate: 1700mg is 1700.0× the Tolerable Upper Intake Level (1.0mg)

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product received a low safety score because it contains 1,700mg of L-Methylfolate, which significantly exceeds the recommended tolerable upper intake level of 1.0mg.

Label

Product Label

Label for L-5-MTHF SAP
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
60
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1700 mcg DFE (425% DV)
Exceeds UL by 1700.0× (UL: 1.0 mg) 226 studies (A:10, B:105)

Other Ingredients

Vegetable Magnesium Stearate Silicon Dioxide Microcrystalline Cellulose Vegetable Hypromellose Water, Purified
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions for use: Adults: Take 1 capsule daily with food or as directed by your healthcare practitioner. If you are taking other medications, take this product a few hours before or after them.

Warnings & Precautions

Cautions and warnings: Folate supplementation can mask a vitamin B12 deficiency; consult a healthcare practitioner if you are uncertain whether or not you are taking adequate vitamin B12.

Do not use if seal is broken.

Keep out of reach of children.

Formulation Notes

L-5-MTHF SAP -- L-methylfolate helps to form red blood cells; helps the body to metabolize proteins; and helps to reduce the risk of neural tube defects when taken daily prior to becoming pregnant and during early pregnancy.

All ingredients listed for this product lot number have been tested by a third-party laboratory for identity, potency, and purity.

Contains no: Gluten, soy, wheat, corn, eggs, dairy, yeast, citrus, preservatives, artificial flavor or color, starch, or sugar.

This product is non-GMO and vegan friendly.

This product is non-GMO and vegan friendly.

Color, size and smell may vary from one lot to another.

L-5-methyltetrahydrofolate

Made in Canada

Additional Information

NPN 80053719

Metadata

Product Details

UPC / SKU8 56711 11100 5
DSLD Entry Date2023-01-23
Product TypeVitamin
FormCapsule
BrandNFH
DSLD ID273328
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.