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St. John's Wort 450

product on market Tablet or Pill Source Naturals Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade
Label

Product Label

Label for St. John's Wort 450
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
180
Servings
Botanical
Product Type
0%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 300.0mg (240 products) 20 studies — no high-quality reviews

Other Ingredients

Dibasic Calcium Phosphate modified Cellulose Gum Microcrystalline Cellulose Stearic Acid Silica Magnesium Stearate
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: 1 tablet twice daily. To obtain the best results, use this product for at least 6 weeks.

Warnings & Precautions

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

Warning: Do not use this product while taking any medication or if you have a medical condition, without the advice of your physician or pharmacist. St. John’s wort is known to interfere with many prescription and non-prescription drugs, including oral contraceptives, antibiotics, antidepressants, anticoagulants, antihistamines, immunosuppressants, corticosteroids, diabetes drugs, antiviral, antiseizure, anticancer and cardiovascular drugs.

It may also cause increased photosensitivity; limit exposure to UV radiation.

If you are pregnant, may become pregnant, or breastfeeding, consult your healthcare professional before using this product.

Formulation Notes

Standardized to 0.3% hypericins 460 mg

Supports a positive mental outlook

Source Naturals St. John's Wort 450 is standardized to consistently supply 0.3% hypericins. A daily intake of St. John’s wort standardized to 2.7 mg hypericins may support a positive outlook and mood. Benefits may be experienced within 4 to 6 weeks of initial use.

Note: Natural plant variations may affect tablet color.

Suitable for Vegetarians.

Contains no yeast, dairy, egg, gluten, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.

Metadata

Product Details

UPC / SKU0 21078 01177 4
DSLD Entry Date2022-08-23
Product TypeBotanical
FormTablet or Pill
DSLD ID273078
Data Updated2026-04-11
Research

Research Evidence

43
Research Sources
48
Avg Quality
16
Meta Analysis
14
Systematic Review
7
Rct
4
Regulatory Source
1
Clinical Trial
1
Openfda Safety
B St John's wort for major depression
Systematic Review The Cochrane database of systematic reviews 2008 PubMed DOI
B Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis
Meta Analysis Journal of affective disorders 2017 PubMed DOI
B A systematic review of St. John's wort for major depressive disorder
Meta Analysis Systematic reviews 2016 PubMed DOI
B St John's wort for depression
Systematic Review The Cochrane database of systematic reviews 2000 PubMed
B Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis
Meta Analysis Neuropsychopharmacology reports 2025 PubMed DOI
B St John's wort for depression
Meta Analysis The Cochrane database of systematic reviews 2005 PubMed
C St John's wort for depression: meta-analysis of randomised controlled trials
Meta Analysis The British journal of psychiatry : the journal of mental science 2005 PubMed
C The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial
Rct Complementary therapies in medicine 2019 PubMed DOI
C Hypericum extract versus imipramine or placebo in patients with moderate depression: randomised multicentre study of treatment for eight weeks
Rct BMJ (Clinical research ed.) 1999 PubMed
C Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis
Meta Analysis Scientific reports 2016 PubMed DOI
View all evidence for St Johns Wort →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.