🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

📸

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Label Data

1 Tablet(s) Serving Size
180 Servings
Botanical Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

📊 Market median: 300.0mg (240 products) 📚 11 studies — no high-quality reviews
This product: 450mg

Other Ingredients

Dibasic Calcium Phosphate modified Cellulose Gum Microcrystalline Cellulose Stearic Acid Silica Magnesium Stearate

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (78% of products) Nutrient (2% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Suggested Use: 1 tablet twice daily. To obtain the best results, use this product for at least 6 weeks.

⚠️ Warnings & Precautions

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

Warning: Do not use this product while taking any medication or if you have a medical condition, without the advice of your physician or pharmacist. St. John’s wort is known to interfere with many prescription and non-prescription drugs, including oral contraceptives, antibiotics, antidepressants, anticoagulants, antihistamines, immunosuppressants, corticosteroids, diabetes drugs, antiviral, antiseizure, anticancer and cardiovascular drugs.

It may also cause increased photosensitivity; limit exposure to UV radiation.

If you are pregnant, may become pregnant, or breastfeeding, consult your healthcare professional before using this product.

🧪 Formulation Notes

Standardized to 0.3% hypericins 460 mg

Supports a positive mental outlook

Source Naturals St. John's Wort 450 is standardized to consistently supply 0.3% hypericins. A daily intake of St. John’s wort standardized to 2.7 mg hypericins may support a positive outlook and mood. Benefits may be experienced within 4 to 6 weeks of initial use.

Note: Natural plant variations may affect tablet color.

Suitable for Vegetarians.

Contains no yeast, dairy, egg, gluten, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.

Product Details

UPC / SKU 0 21078 01177 4
DSLD Entry Date 2022-08-23
Product Type Botanical
Form Tablet or Pill
DSLD ID 273078
Data Updated 2026-04-11

Research Evidence

43 Research Sources
48 Avg Quality Score
16 Meta Analysis
14 Systematic Review
7 Rct
4 Regulatory Source
1 Clinical Trial
1 Openfda Safety
B St John's wort for major depression
Systematic Review The Cochrane database of systematic reviews 2008
B Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis
Meta Analysis Journal of affective disorders 2017
B A systematic review of St. John's wort for major depressive disorder
Meta Analysis Systematic reviews 2016
B St John's wort for depression
Systematic Review The Cochrane database of systematic reviews 2000
B Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis
Meta Analysis Neuropsychopharmacology reports 2025
B St John's wort for depression
Meta Analysis The Cochrane database of systematic reviews 2005
C St John's wort for depression: meta-analysis of randomised controlled trials
Meta Analysis The British journal of psychiatry : the journal of mental science 2005
C The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial
Rct Complementary therapies in medicine 2019
C Hypericum extract versus imipramine or placebo in patients with moderate depression: randomised multicentre study of treatment for eight weeks
Rct BMJ (Clinical research ed.) 1999
C Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis
Meta Analysis Scientific reports 2016
View all evidence for St Johns Wort →

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