Homocysteine Defense

product on market Tablet or Pill Source Naturals 🟢 Safety: 95/100
Brand: Source Naturals
🟢 95/100

This product looks safe

  • Folate: 1360mg is 1360.0× the Tolerable Upper Intake Level (1.0mg)
  • 43% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 1360mg is 1360.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

2 Tablet(s) Serving Size
60 Servings
Other Combinations Product Type
43% Evidence Coverage

Supplement Facts — Evidence Check

Calories
5 Calorie(s)
Protein
1 Gram(s) (2% DV)
50 mg (2941% DV)
📊 38.5× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 50mg UL 100mg
1360 mcg DFE (340% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1360.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 1360mg UL 1.0mg
500 mcg (20833% DV)
📊 208.3× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.5mg
Calcium
90 mg (7% DV)
1 Gram(s)
📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 1mg

Other Ingredients

Dibasic Calcium Phosphate Stearic Acid modified Cellulose Gum Silica Magnesium Stearate

Label Claims — Verification

❓ Nutrient
❓ All Other
❓ Structure/Function
All Other (98% of products) Structure/Function (89% of products) Nutrient (43% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested Use: 2 tablets daily.

⚠️ Warnings & Precautions

Note: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

🧪 Formulation Notes

Helps support the cardiovascular system

Source Naturals Homocysteine Defense is an excellent formula which may provide support to the cardiovascular system.

Source Naturals Homocysteine Defense is an excellent formula which may provide support to the cardiovascular system. Trimethylglycine (TMG), vitamins B-6, B-12, and folic acid may help in the conversion of homocysteine to other substances, including methionine, thus preventing an unwanted build-up of homocysteine.*

Suitable for vegetarians.

Contains no yeast, dairy, egg, gluten, corn, soy or wheat. Contains no starch, preservatives, or artificial color, flavor or fragrance.

Additional Information

Store in a cool, dry place.

Product Details

UPC / SKU 0 21078 01039 5
DSLD Entry Date 2022-08-23
Product Type Other Combinations
Form Tablet or Pill
Brand Source Naturals
DSLD ID 273056
Data Updated 2026-04-11

Research Evidence

153 Research Sources
55 Avg Quality Score
71 Systematic Review
51 Meta Analysis
19 Rct
6 Clinical Trial
2 Other
2 Regulatory Source
1 Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013
PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009
PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
PubMed DOI Cochrane
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021
PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016
PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020
PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006
PubMed Cochrane
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022
PubMed DOI
View all evidence for Vitamin B6 →

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