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Homocysteine Defense

product on market Tablet or Pill Source Naturals Safety: 95/100
95/100

This product looks safe

  • Folate: 1360mg is 1360.0× the Tolerable Upper Intake Level (1.0mg)
  • 43% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Vitamin B6, folate, and B12 are supported by strong evidence for their role in lowering homocysteine levels. These nutrients act as essential cofactors in the methylation process to support cardiovascular health. The evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 1360mg is 1360.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Homocysteine Defense
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Tablet(s)
Serving Size
60
Servings
Other Combinations
Product Type
43%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
5 Calorie(s)
Protein
1 Gram(s) (2% DV)
50 mg (2941% DV)
38.5× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
1360 mcg DFE (340% DV)
Exceeds UL by 1360.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
500 mcg (20833% DV)
208.3× RDA — above typical dose 139 studies (A:1, B:44)
Calcium
90 mg (7% DV)
1 Gram(s)
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews

Other Ingredients

Dibasic Calcium Phosphate Stearic Acid modified Cellulose Gum Silica Magnesium Stearate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: 2 tablets daily.

Warnings & Precautions

Note: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

Formulation Notes

Helps support the cardiovascular system

Source Naturals Homocysteine Defense is an excellent formula which may provide support to the cardiovascular system.

Source Naturals Homocysteine Defense is an excellent formula which may provide support to the cardiovascular system. Trimethylglycine (TMG), vitamins B-6, B-12, and folic acid may help in the conversion of homocysteine to other substances, including methionine, thus preventing an unwanted build-up of homocysteine.*

Suitable for vegetarians.

Contains no yeast, dairy, egg, gluten, corn, soy or wheat. Contains no starch, preservatives, or artificial color, flavor or fragrance.

Additional Information

Store in a cool, dry place.

Metadata

Product Details

UPC / SKU0 21078 01039 5
DSLD Entry Date2022-08-23
Product TypeOther Combinations
FormTablet or Pill
BrandSource Naturals
DSLD ID273056
Data Updated2026-04-11
Research

Research Evidence

153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016 PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020 PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 PubMed DOI
View all evidence for Vitamin B6 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.