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Niacin

product on market Capsule Member's Mark Safety: 80/100
80/100

This product is generally safe

  • Niacin: 400mg is 11.4× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Niacin is supported by strong evidence for managing lipid levels and supporting metabolic function. Inositol has moderate evidence for improving insulin sensitivity and supporting cellular signaling. Together, these ingredients target metabolic health, though overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 400mg is 11.4× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for Niacin
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
200
Servings
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

400 mg (2500% DV)
Exceeds UL by 11.4× (UL: 35 mg) 196 studies (A:5, B:63)
100 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)

Other Ingredients

Gelatin Stearic Acid Silica Magnesium Stearate
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: For adults, take one (1) capsule daily, preferably with a meal. As a reminder, discuss the supplements and medications you take with your health care providers.

Warnings & Precautions

Keep out of the reach of children.

Warning: Not intended for use by pregnant or nursing women. If you are taking any medications or have any medical condition, consult your doctor if any adverse reactions occur.

Notice: Most people should not experience flushing when using this product. However, a few sensitive individuals may experience a temporary skin flushing (hot feeling and skin redness), buring, itching, or rash caused by an increase in blood flow near the skin.

Do not take more than the recommended dose unless prescribed by your doctor.

Tamper resistant: Do not use if seal under cap is broken or missing.

Formulation Notes

Supports Energy Metabolism

Health Benefits Energy

Supports carbohydrate and protein metabolism

Flush free Niacin Inositol Hexanicotinate 500 mg per capsule per day

Nutrition Information: Niacin, also called Vitamin B3, is part of a coenzyme needed for energy metabolism. Niacin helps maintain healthy functions of the nervous system and skin. Flush free means that you don't experience the familiar "flush" when using this supplement.

No sugar, no synthetic dyes, no milk or milk derivatives, no lactose, no wheat, no artificial flavors, no preservatives, no gluten, no yeast, no soy, no sodium (less than 5 mg per serving)

This product does not contain FD&C colors or dyes

Additional Information

Questions or Comments? We would love to hear about your Member's Mark experience! In the continental U.S. or Canada, you can call us at 1-888-698-5034 from 8:30 a.m. to 5:00 p.m. EST Monday - Friday.

Store at room temperature, tightly closed and avoid excessive heat.

Metadata

Product Details

UPC / SKU1 93968 03022 3
DSLD Entry Date2022-08-23
Product TypeNon-Nutrient/Non-Botanical
FormCapsule
DSLD ID272788
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.