🟢 80/100

This product is generally safe

  • Niacin: 400mg is 11.4× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 400mg is 11.4× the Tolerable Upper Intake Level (35mg)

Label Data

1 Capsule(s) Serving Size
200 Servings
Non-Nutrient/Non-Botanical Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

400 mg (2500% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 11.4× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 400mg UL 35mg
100 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 100mg

Other Ingredients

Gelatin Stearic Acid Silica Magnesium Stearate

Label Claims — Verification

All Other
Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Suggested Use: For adults, take one (1) capsule daily, preferably with a meal. As a reminder, discuss the supplements and medications you take with your health care providers.

⚠️ Warnings & Precautions

Keep out of the reach of children.

Warning: Not intended for use by pregnant or nursing women. If you are taking any medications or have any medical condition, consult your doctor if any adverse reactions occur.

Notice: Most people should not experience flushing when using this product. However, a few sensitive individuals may experience a temporary skin flushing (hot feeling and skin redness), buring, itching, or rash caused by an increase in blood flow near the skin.

Do not take more than the recommended dose unless prescribed by your doctor.

Tamper resistant: Do not use if seal under cap is broken or missing.

🧪 Formulation Notes

Supports Energy Metabolism

Health Benefits Energy

Supports carbohydrate and protein metabolism

Flush free Niacin Inositol Hexanicotinate 500 mg per capsule per day

Nutrition Information: Niacin, also called Vitamin B3, is part of a coenzyme needed for energy metabolism. Niacin helps maintain healthy functions of the nervous system and skin. Flush free means that you don't experience the familiar "flush" when using this supplement.

No sugar, no synthetic dyes, no milk or milk derivatives, no lactose, no wheat, no artificial flavors, no preservatives, no gluten, no yeast, no soy, no sodium (less than 5 mg per serving)

This product does not contain FD&C colors or dyes

Additional Information

Questions or Comments? We would love to hear about your Member's Mark experience! In the continental U.S. or Canada, you can call us at 1-888-698-5034 from 8:30 a.m. to 5:00 p.m. EST Monday - Friday.

Store at room temperature, tightly closed and avoid excessive heat.

Product Details

UPC / SKU 1 93968 03022 3
DSLD Entry Date 2022-08-23
Product Type Non-Nutrient/Non-Botanical
Form Capsule
DSLD ID 272788
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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