Cardio SAP by NFH — Ingredients, Evidence & Safety

Product Label

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Safety Alerts

⚠️ L-Methylfolate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Capsule(s) Serving Size

60 Servings

Other Combinations Product Type

75% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin B6

20 mg (1176% DV)

📊 15.4× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 20mg UL 100mg

L-Methylfolate

680 mcg DFE (170% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 680.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 680mg UL 1.0mg

Vitamin B12

500 mcg (20833% DV)

📊 208.3× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.5mg

Betaine

668 mg

📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews

This product: 668mg

Other Ingredients

Microcrystalline Cellulose Vegetable Magnesium Stearate Silicon Dioxide Hypromellose Water, Purified

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (98% of products) Structure/Function (89% of products) Nutrient (43% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Directions for use: Adults take 1 capsule once or twice daily or as directed by your healthcare practitioner.

Keep in a cool and dry place. Ensure lid is closed properly after each use.

⚠️ Warnings & Precautions

Do not use if seal is broken.

Keep out of reach of children.

🧪 Formulation Notes

Cardio SAP is a science-based blend of B-vitamins and betaine to promote healthy homocysteine levels and support cardiovascular health. Cardio SAP provides the activated enzyme forms methylcobalamin, pyridoxal-5'-phospahate, and trimethylglycine for optimal bioavailability and enhanced efficacy.

All ingredients listed for this product lot number have been tested by a third-party laboratory for identity, potency, and purity.

Contains no: Gluten, soy, wheat, corn, eggs, dairy, yeast, citrus, preservatives, artificial flavor or color, starch, or sugar.

This product is non-GMO and vegan friendly.

Homocysteine support

Additional Information

NPN 80047420

Product Details

UPC / SKU 8 56711 00110 8

DSLD Entry Date 2022-08-23

Product Type Other Combinations

Form Capsule

Brand NFH

DSLD ID 272769

Data Updated 2026-04-11

Research Evidence

153 Research Sources

55 Avg Quality Score

71 Systematic Review

51 Meta Analysis

19 Rct

6 Clinical Trial

2 Other

2 Regulatory Source

1 Openfda Safety

A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials

Meta Analysis BMJ (Clinical research ed.) 2013

PubMed DOI

A Homocysteine lowering interventions for preventing cardiovascular events

Meta Analysis The Cochrane database of systematic reviews 2009

PubMed DOI

A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies

Meta Analysis Critical reviews in food science and nutrition 2019

PubMed DOI

A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study

Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024

PubMed DOI

A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI Cochrane

B Prophylactic drug management for febrile seizures in children

Meta Analysis The Cochrane database of systematic reviews 2021

PubMed DOI

B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review

Systematic Review JAMA 2016

PubMed DOI

B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies

Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020

PubMed DOI

B Pyridoxine (vitamin B6) supplementation in pregnancy

Meta Analysis The Cochrane database of systematic reviews 2006

PubMed Cochrane

B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis

Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022

PubMed DOI

View all evidence for Vitamin B6 →