Home/ Supplements/ Folate/ B12 Methyl Factors

B12 Methyl Factors

product on market Tablet or Pill HoltraCeuticals Safety: 80/100
80/100

This product is generally safe

  • Folate: 1700mg is 1700.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Folate and vitamin B12 are essential nutrients that support neurological function and red blood cell formation. Strong clinical evidence supports their role in maintaining homocysteine levels and cognitive health. However, the specific evidence coverage for this product's formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 1700mg is 1700.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for B12 Methyl Factors
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
60
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1700 mcg DFE (425% DV)
Exceeds UL by 1700.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
5000 mcg (208333% DV)
2083.3× RDA — above typical dose 139 studies (A:1, B:44)

Other Ingredients

Isomalt natural Cane Sugar Croscarmellose Sodium Potassium Bicarbonate natural Cherry flavor Sodium Stearyl Fumarate Stearic Acid Citric Acid Silicon Dioxide Bilberry fruit extract
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: 1 tablet per day or as recommended by your health care professional.

Warnings & Precautions

If you are pregnant or nursing, consult your physician before taking this product.

As with all dietary supplements, some individuals may not tolerate or may be allergic to the ingredients used. Please read the ingredient panel carefully prior to ingestion. Cease taking this product and consult your physician if you have negative reactions upon ingestion.

Caution: This product contains a desiccant. For best results, keep the desiccant in the bottle until all contents are consumed. Do not eat desiccant. This product was sealed for your protection. Do not use if outer logoed neck seal or inner-seal is missing or damaged.

Keep out of reach of children.

Formulation Notes

Formulated to be free of allergens derived from: Gluten, yeast, artificial colors and flavors.

Boost energy and cognitive function

Additional Information

Keep container tightly closed. Store at room temperature.

To re-order visit HoltraCeuticals.com

Metadata

Product Details

UPC / SKU6 15033 60599 5
DSLD Entry Date2022-08-23
Product TypeVitamin
FormTablet or Pill
BrandHoltraCeuticals
DSLD ID272688
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
View all evidence for Folate →
Compare

Similar Products

Maximum Strength Folic Acid 800 mcg
Nature's Bounty · Tablet or Pill
100
Folic Acid 800 mcg
VitaCeutical Labs · Tablet or Pill
100
Folic Acid 800 mcg With 25 mcg Vitamin B-12
Vitabase · Tablet or Pill
100
Natural Folic Acid 400 mcg
Equaline · Tablet or Pill
100
Folic Acid 400 mcg Supplement
Nature Made · Tablet or Pill
100
View all Folate products →
Folate research Best Folate All Folate products More from HoltraCeuticals View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.