Home/ Supplements/ Same/ SAMe 400 mg

SAMe 400 mg

product on market Tablet or Pill Lake Avenue Nutrition Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

SAMe is used to support mood and joint health, with moderate evidence suggesting its efficacy in managing depressive symptoms. Research indicates it may act as a methyl donor in various biochemical reactions. Clinical data for these applications is generally supportive, though evidence coverage for this specific formulation remains limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for SAMe 400 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
60
Servings
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

400 mg
Market median: 200.0mg (52 products) 12 studies (A:0, B:6)

Other Ingredients

Microcrystalline Cellulose Croscarmellose Sodium Ascorbyl Palmitate Silicon Dioxide Ascorbic Acid Citric Acid Methacrylic Acid Copolymer Hydroxypropyl Methylcellulose Polyethylene Glycol Triacetin Titanium Dioxide Riboflavin
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: Take 1 tablet daily with or without food, or as recommended by a healthcare practitioner.

Warnings & Precautions

Warnings: Keep out of reach of children.

As with all dietary supplements, it is recommended to consult with a healthcare professional before adding something new to your health and wellness regimen. Sealed for your protection, do not use if seal is missing or damaged.

Not manufactured with milk, egg, fish, shellfish, tree nuts, peanuts, wheat, soy, sesame, or gluten. Produced in a third-party cGMP facility that may process other products that contain these allergens or ingredients.

Formulation Notes

(from S-adenosyl-L-methionine disulfate tosylate)

Supports joint, mood, and liver health

Formulated without: GMOs Gluten Soy

Not manufactured with milk, egg, fish, shellfish, tree nuts, peanuts, wheat, soy, sesame, or gluten.

Additional Information

Store in a cool, dry place.

Metadata

Product Details

UPC / SKU8 98220 01651 8
DSLD Entry Date2023-03-22
Product TypeNon-Nutrient/Non-Botanical
FormTablet or Pill
DSLD ID272672
Data Updated2026-04-11
Research

Research Evidence

12
Research Sources
58
Avg Quality
8
Meta Analysis
3
Systematic Review
1
Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024 PubMed DOI
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024 PubMed DOI
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024 PubMed DOI
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015 PubMed DOI
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024 PubMed DOI
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024 PubMed DOI
View all evidence for Same →
Compare

Similar Products

View all Same products →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.