🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 33% of ingredients have research evidence
A Label Compliance Grade

Product Label

📸

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Label Data

1 Softgel(s) Serving Size
30 Servings
Non-Nutrient/Non-Botanical Product Type
33% Evidence Coverage

Supplement Facts — Evidence Check

Calories
5 Calorie(s)
0.5 mg (38% DV)
✅ Within RDA (0.4× RDA of 1.3 mg) 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 0.5mg
📊 Market median: 200.0mg (198 products) 📚 6 studies — no high-quality reviews
This product: 200mg

Other Ingredients

Medium Chain Triglycerides Gelatin Glycerin Rapeseed Lecithin Water Soybean Oil yellow Beeswax

Label Claims — Verification

All Other
Structure/Function
All Other (98% of products) Structure/Function (87% of products) Nutrient (16% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free

Product Information

📋 Directions for Use

Suggested Use: Adults, take 1 softgel daily on an empty stomach.

⚠️ Warnings & Precautions

Store tightly closed, in a cool, dry place, out of reach of children.

Do not use if imprinted seal under cap is broken or missing.

Caution: Do not take if pregnant or nursing.

If you have diabetes or are glucose-intolerant, consult your physician before use.

🧪 Formulation Notes

Antioxidant activity that helps neutralize free radicals

No artificial flavors No preservatives Gluten free

Encapsulated and Quality Tested in the USA. Made to our guaranteed purity and potency standards.

Additional Information

Store tightly closed, in a cool, dry place, out of reach of children.

Product Details

DSLD Entry Date 2022-06-16
Product Type Non-Nutrient/Non-Botanical
Form Softgel Capsule
Brand Nature Made
DSLD ID 270951
Data Updated 2026-04-11

Research Evidence

21 Research Sources
52 Avg Quality Score
13 Rct
4 Meta Analysis
2 Systematic Review
2 Clinical Trial
A Alpha-lipoic acid for diabetic peripheral neuropathy
Systematic Review The Cochrane database of systematic reviews 2024
B Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy
Rct Nutrients 2024
B Alpha Lipoic Acid Supplementation and Iron Homeostasis: A Comprehensive Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Meta Analysis International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 2024
B Effectiveness of alpha-lipoic acid in patients with neuropathic pain associated with type I and type II diabetes mellitus: A systematic review and meta-analysis
Meta Analysis Medicine 2023
C The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Metabolism: clinical and experimental 2018
C A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy
Meta Analysis European journal of endocrinology 2012
C Oral Alpha Lipoic Acid Treatment for Symptomatic Diabetic Peripheral Neuropathy: A Randomized Double-Blinded Placebo-Controlled Study
Rct Endocrine, metabolic & immune disorders drug targets 2020
C A randomized, double-blind, placebo controlled study to evaluate the effect of alpha-lipoic acid on inhibition of ADP-and collagen-induced platelet aggregation ex vivo in diabetic neuropathy patients on gabapentin or pregabalin
Rct Journal of postgraduate medicine 2024
C Ranking Alpha Lipoic Acid and Gamma Linolenic Acid in Terms of Efficacy and Safety in the Management of Adults With Diabetic Peripheral Neuropathy: A Systematic Review and Network Meta-analysis
Systematic Review Canadian journal of diabetes 2024
C Effect analysis of tanshinone IIA sulfonate sodium combined with a-lipoic acid in patients with diabetes peripheral neuropathy.
Rct Pakistan journal of pharmaceutical sciences
View all evidence for Alpha Lipoic Acid →

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