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5-HTP w/SRT

product on market Tablet or Pill Jigsaw Health Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

L-5-Hydroxytryptophan serves as a precursor to serotonin, with moderate evidence supporting its use for mood regulation and sleep. Research indicates it may help alleviate symptoms of depression by increasing serotonin levels in the brain. The overall evidence coverage for this specific formulation remains limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP w/SRT
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
120
Servings
Amino acid/Protein
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 100.0mg (116 products) 18 studies (A:0, B:3)

Other Ingredients

Microcrystalline Cellulose Stearic Acid Guar Gum Hydroxypropyl Cellulose Magnesium Stearate Croscarmellose Sodium Xanthan Gum Clear Coating Silicon Dioxide Micro Wax
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: Take 1 tablet daily, with or without food. Or use as directed by your healthcare professional.

Warnings & Precautions

Should not be used if tamper evident seal is broken.

Keep out of reach of children.

Formulation Notes

5-HTP is the raw material your body uses to make serotonin, the master mood-regulating neurotransmitter. Increasing the amount of 5-HTP in your body supports serotonin production. Because 5-HTP has a very short half-life in the body, we employ our patented Sustained Release Technology (SRT), so that you can get a longer-lasting effect. And to ensure you get the highest quality of 5-HTP available, we use only the highest quality form from the seeds of the Griffonia simplicifolia tree found primarily in the West African countries.

5-Hydroxytryptophan

Maintains mental and emotional well-being. 8 hours

Non-GMO Gluten free

Vegan

Label claim verified

Additional Information

Need more? Call 1-888-352-5050 or visit jigsawhealth.com

Store in a cool dry place.

Please recycle

Product of the U.S.A. with select ingredients thoughtfully curated from around the world.

Metadata

Product Details

UPC / SKU8 76634 00017 0
DSLD Entry Date2022-06-16
Product TypeAmino acid/Protein
FormTablet or Pill
DSLD ID270381
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.