🟢 80/100

This product is generally safe

  • Niacin: 375mg is 10.7× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 375mg is 10.7× the Tolerable Upper Intake Level (35mg)

Label Data

1 Capsule(s) Serving Size
60 Servings
Other Combinations Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

375 mg (2340% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 10.7× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 375mg UL 35mg
91 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 91mg

Other Ingredients

Plant-Source Capsule

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Kosher

Product Information

📋 Directions for Use

Suggested Use: Take 1 capsule daily or as directed by a health professional.

⚠️ Warnings & Precautions

Keep out of reach of children.

Tamper Seal: Use only if seal is intact.

Consult your health care practitioner if you are pregnant/nursing, taking medications or have a medical condition, before taking this or any other product.

🧪 Formulation Notes

A special form of vitamin B-3 (inositol hexanicotinate) which eliminates the unpleasant flushing effect of niacin

Promotes healthy cardiovascular support as well as blood flow and glucose utilization

Vitamin B3 is a key nutrient involved in energy metabolism, formation of skin and digestive tissues.

OU (Kosher) We are proud to offer many OU Kosher Certified products.

No flush form Vitamin B3 as inositol hexanicotinate

PRL's quality guarantee Potency verified Purity verified Forensic tested for adulterants No chemical or radiation sterilization Pathogen microbiology performed Heavy metal tested FDA-monitored cGMP facility

Pure vegan

No added magnesium stearate PRL's quality program. Manufactured to avoid: added magnesium stearate (an undesirable excipient), artificial colors, artificial flavors or artificial preservatives.

Additional Information

OU (Kosher) We are proud to offer many OU Kosher Certified products.

Store in a cool, dry place.

Product Details

DSLD Entry Date 2022-06-16
Product Type Other Combinations
Form Capsule
DSLD ID 270010
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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