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Premier Niacin

product on market Capsule Premier Research Labs Safety: 80/100
80/100

This product is generally safe

  • Niacin: 375mg is 10.7× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Niacin is supported by strong evidence for improving lipid profiles and cardiovascular health. Inositol has moderate evidence for supporting insulin sensitivity and metabolic function. Together, these ingredients target metabolic support, though the overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 375mg is 10.7× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for Premier Niacin
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
60
Servings
Other Combinations
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

375 mg (2340% DV)
Exceeds UL by 10.7× (UL: 35 mg) 196 studies (A:5, B:63)
91 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)

Other Ingredients

Plant-Source Capsule
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: Take 1 capsule daily or as directed by a health professional.

Warnings & Precautions

Keep out of reach of children.

Tamper Seal: Use only if seal is intact.

Consult your health care practitioner if you are pregnant/nursing, taking medications or have a medical condition, before taking this or any other product.

Formulation Notes

A special form of vitamin B-3 (inositol hexanicotinate) which eliminates the unpleasant flushing effect of niacin

Promotes healthy cardiovascular support as well as blood flow and glucose utilization

Vitamin B3 is a key nutrient involved in energy metabolism, formation of skin and digestive tissues.

OU (Kosher) We are proud to offer many OU Kosher Certified products.

No flush form Vitamin B3 as inositol hexanicotinate

PRL's quality guarantee Potency verified Purity verified Forensic tested for adulterants No chemical or radiation sterilization Pathogen microbiology performed Heavy metal tested FDA-monitored cGMP facility

Pure vegan

No added magnesium stearate PRL's quality program. Manufactured to avoid: added magnesium stearate (an undesirable excipient), artificial colors, artificial flavors or artificial preservatives.

Additional Information

OU (Kosher) We are proud to offer many OU Kosher Certified products.

Store in a cool, dry place.

Metadata

Product Details

DSLD Entry Date2022-06-16
Product TypeOther Combinations
FormCapsule
BrandPremier Research Labs
DSLD ID270010
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.