🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Vegetarian Capsule(s) Serving Size
120 Servings
Vitamin Product Type
50% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin C
40 mg (67% DV)
800 mcg (200% DV)
✅ 2.0× RDA — within safe limits 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 0.8mg UL 1.0mg

Other Ingredients

Vegetarian Capsule Microcrystalline Cellulose

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (77% of products) Nutrient (60% of products) Approved Health (5% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: As a dietary supplement for adults, take one (1) vegetarian capsule daily, preferably with a meal, or as directed by a physician.

⚠️ Warnings & Precautions

Keep out of reach of children

Caution: Consult a physician before use if you are pregnant, nursing, taking medication or have a medical condition.

🧪 Formulation Notes

Healthy Origins BioActive Methyl Folate (featuring Quatrefolic) is the more stable, bioavailable, and soluble form of folate. Traditional folic acid supplements are not biologically active and need to be converted to the metabolically active 5-Methyltetrahydrofolate (5-MTHF) form. This conversion is done through a multi-step process in the body where the enzyme. Methylenetetrahydrofolate reductase (MTHFR) plays a key role. Some individuals, due to their unique genetic patterns and expression, have polymorphic forms of this enzyme and do not produce adequate or effective MTHFR. Inadequate or ineffective MTHFR enzyme production makes the conversion of folic acid to active 5-MTHF very difficult.

Bioactive The more stable, bioavailable, and soluble form of folate

Quatrefolic

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, peanut, or tree nut derived ingredients. Non GMO

Manufactured in a cGMP facility.

Suitable for vegans

Additional Information

Store in a cool, dry place.

New look

3rd Party Tested

Product Details

UPC / SKU 6 03573 88319 5
DSLD Entry Date 2022-07-21
Product Type Vitamin
Form Capsule
DSLD ID 269396
Data Updated 2026-04-11

Research Evidence

363 Research Sources
57 Avg Quality Score
187 Meta Analysis
56 Systematic Review
54 Rct
29 Guideline
26 Clinical Trial
6 Cochrane Review
2 Regulatory Source
1 Other
1 Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025
View all evidence for Folate →

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