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Methyl Folate 800 mcg

product on market Capsule Healthy Origins Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

Vitamin C and folate are supported by strong evidence for their roles in antioxidant protection and cellular synthesis. These ingredients contribute to overall metabolic function and DNA methylation. Current research indicates a high safety profile for these nutrients at the specified dosages.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Methyl Folate 800 mcg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Vegetarian Capsule(s)
Serving Size
120
Servings
Vitamin
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin C
40 mg (67% DV)
800 mcg (200% DV)
2.0× RDA — within safe limits 226 studies (A:10, B:105)

Other Ingredients

Vegetarian Capsule Microcrystalline Cellulose
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement for adults, take one (1) vegetarian capsule daily, preferably with a meal, or as directed by a physician.

Warnings & Precautions

Keep out of reach of children

Caution: Consult a physician before use if you are pregnant, nursing, taking medication or have a medical condition.

Formulation Notes

Healthy Origins BioActive Methyl Folate (featuring Quatrefolic) is the more stable, bioavailable, and soluble form of folate. Traditional folic acid supplements are not biologically active and need to be converted to the metabolically active 5-Methyltetrahydrofolate (5-MTHF) form. This conversion is done through a multi-step process in the body where the enzyme. Methylenetetrahydrofolate reductase (MTHFR) plays a key role. Some individuals, due to their unique genetic patterns and expression, have polymorphic forms of this enzyme and do not produce adequate or effective MTHFR. Inadequate or ineffective MTHFR enzyme production makes the conversion of folic acid to active 5-MTHF very difficult.

Bioactive The more stable, bioavailable, and soluble form of folate

Quatrefolic

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, peanut, or tree nut derived ingredients. Non GMO

Manufactured in a cGMP facility.

Suitable for vegans

Additional Information

Store in a cool, dry place.

New look

3rd Party Tested

Metadata

Product Details

UPC / SKU6 03573 88319 5
DSLD Entry Date2022-07-21
Product TypeVitamin
FormCapsule
DSLD ID269396
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.