Folgard RX Tablets

product on market Tablet or Pill Upsher-Smith 🟢 Safety: 87/100
Brand: Upsher-Smith
🟢 87/100

This product is generally safe

  • Folic Acid: 2.2mg is 2.2× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folic Acid: 2.2mg is 2.2× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Tablet(s) Serving Size
Vitamin Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

2.2 mg
⚠️ Exceeds Tolerable Upper Intake Level by 2.2× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 2.2mg UL 1.0mg
25 mg
📊 19.2× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 25mg UL 100mg
1 mg
📊 416.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 1mg

Other Ingredients

Dibasic Calcium Phosphate Carnauba Wax Citric Acid FD&C Blue #2 Aluminum Lake FD&C Red #40 Aluminum Lake FD&C yellow #5/tartrazine aluminum lake Hypromellose Magnesium Stearate Microcrystalline Cellulose modified Food Starch Polyethylene Glycol Polysorbate 80 Silicon Dioxide Sodium Citrate Sodium Starch Glycolate Stearic Acid Titanium Dioxide

Label Claims — Verification

❓ Nutrient
❓ All Other
All Other (99% of products) Structure/Function (77% of products) Nutrient (60% of products) Approved Health (5% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Usual Dose: Adults - one tablet daily or as directed by a physician.

⚠️ Warnings & Precautions

Precautions: Folic Acid in doses above 0.1 mg daily may obscure pernicious anemia in that hematologic remission can occur while neurological manifestations remain progressive.

This product contains FD&C Yellow #5 (tartrazine) which may cause allergic-type reactions (including bronchial asthma) in certain susceptible persons. Although the over-all incidence of FD&C Yellow #5 (tartrazine) sensitivity in the general population is low, it is frequently seen in patients who also have aspirin hypersensitivity.

Keep out of reach of children.

🧪 Formulation Notes

Contains color additives including FD&C Yellow #5 (tartrazine).

2.2 mg Folic Acid, 25 mg Vitamin B-6, 1 mg Vitamin B-12, Combination

With 1 mg B-12

Additional Information

Rx only

Store at controlled room temperature, 15-30(0)C (59-86(0)F). Protect from light and moisture. Dispense in tight container with a child-resistant closure.

9C878 KU F2 R0213

N

Product Details

UPC / SKU 3 0245-0191-11 7
DSLD Entry Date 2013-10-25
Product Type Vitamin
Form Tablet or Pill
Brand Upsher-Smith
DSLD ID 26627
Data Updated 2026-04-11

Research Evidence

363 Research Sources
57 Avg Quality Score
187 Meta Analysis
56 Systematic Review
54 Rct
29 Guideline
26 Clinical Trial
6 Cochrane Review
2 Regulatory Source
1 Other
1 Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021
PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021
PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024
PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025
PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022
PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023
PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025
PubMed DOI
View all evidence for Folate →

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