5-HTP 100

product on market Capsule DC 🟢 Safety: 100/100
Brand: DC
🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Capsule(s) Serving Size
60 Servings
Botanical with Nutrients Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

5 mg (25% DV)
✅ Within RDA (0.4× RDA of 14 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 5mg UL 35mg
5 mg (250% DV)
📊 3.8× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 5mg UL 100mg
25 mg (6% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 25mg
100 mg
📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)
This product: 100mg
50 mg
📊 Market median: 300.0mg (214 products) 📚 23 studies (Tier A: 0, B: 6)
This product: 50mg

Other Ingredients

Calcium Phosphate Gelatin Silica Vegetable Magnesium Stearate

Label Claims — Verification

❓ Nutrient
❓ All Other
All Other (99% of products) Structure/Function (78% of products) Nutrient (52% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free

Product Information

📋 Directions for Use

Directions: As a dietary supplement, start with a low dose of 1 capsule taken with a meal. Increase the dose slowly (every 3-5 days) up to a maximum of 4 capsules taken daily. Total daily intake should be divided into two or more doses, with no more than 2 capsules per dose.

⚠️ Warnings & Precautions

Tamper Evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Keep out of reach of children. Caution: This product should not be taken by children, pregnant or lactating women.

Caution: This product should not be taken by children, pregnant or lactating women.

May cause gastrointestinal upset, diarrhea or nausea which usually disappears by reducing dosage or is minimized by taking with food. As with any supplement, if discomfort persists discontinue use. Those suffering from gut disorders such as ulcers, irritable bowel disease, Crohn's disease, celiac disease, etc., should not use 5-HTP.

Those using MAO-inhibitors, antidepressants and drugs containing fenfluramine should not use 5-HTP.

May cause drowsiness. Do not use while driving or operating machinery.

🧪 Formulation Notes

5-HTP is the precursor to serotonin, a mood and appetite regulating neurotransmitter produced within the body. It has been combined with Valerian, Niacin, Magnesium and Vitamin B-6, an important cofactor in the conversion to serotonin. We use a natural extract that is buffered to minimize any potential gastric discomfort.

Mfg. in an FDA Registered Facility using Good Manufacturing Practices (GMPs)

Gluten free

Hydroxytryptophan with valerian, vitamin B-6, niacin, & magnesium Natural griffonia seed extract

Precursor to serotonin

Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability. Made in USA

Additional Information

Keep tightly closed. Store at room temperature: 59 degrees - 86 degrees F (15 degrees to 30 degrees C).

Quali Pure

Product Details

DSLD Entry Date 2022-01-22
Product Type Botanical with Nutrients
Form Capsule
Brand DC
DSLD ID 265564
Data Updated 2026-04-11

Research Evidence

21 Research Sources
53 Avg Quality Score
11 Systematic Review
6 Rct
4 Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018
PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001
PubMed Cochrane
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002
PubMed Cochrane
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024
PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025
PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023
PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025
PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010
PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020
PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025
PubMed DOI
View all evidence for 5 Htp →

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