Home/ Supplements/ Folate/ Methylfolate

Methylfolate

product on market Capsule Advanced Nutrition by Zahler Safety: 60/100
60/100

Review before taking

  • Folate: 1000mg is 1000.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Methylfolate provides a bioactive form of folate used in cellular processes and DNA synthesis, with strong evidence supporting its role in folate deficiency. However, the low evidence coverage for this specific formulation and a safety score of 60 suggest potential concerns regarding purity or dosage. Users should exercise caution due to these safety indicators.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 1000mg is 1000.0× the Tolerable Upper Intake Level (1.0mg)

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product received a low safety score because it contains 1,000 times the recommended upper limit of folate. This amount significantly exceeds the daily level considered safe for most people.

Label

Product Label

Label for Methylfolate
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
60
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1000 mcg DFE (250% DV)
Exceeds UL by 1000.0× (UL: 1.0 mg) 226 studies (A:10, B:105)

Other Ingredients

Hypromellose Rice Rice Extract Blend
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take 1 capsule daily with food, or as directed by a healthcare practitioner.

Warnings & Precautions

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

If pregnant, nursing or on medication, consult with your healthcare practitioner.

Formulation Notes

Stable and active folate formula Zahler's Methylfolate is a stable and active form of folic acid. This important vitamin helps produce red blood cells, supports tissue health, and is essential for the normal functioning of the brain and nervous system. Adequate intake of folic acid during pregnancy helps support healthy fetal development.

Kosher Pareve Under the strict supervision of Rabbi SH. Stern & the orthodox union

Non-GMO Gluten free Dairy free Soy free

Vegetarian friendly

Stable and active folate formula

Supports healthy fetal development

Additional Information

You may need additional supplements to support a healthy diet; consult your nutritionist for a formula that is right for you or contact us at 877-ASK-ZAHLER (877-275-9245) or ask@zahlers.com.

D (Dairy Kosher) OU (Kosher) This product was manufactured in a GMP certified Facility

Store tightly closed in a cool, dry place.

Made in the USA

General health

Metadata

Product Details

UPC / SKU8 48998 08192 8
DSLD Entry Date2022-02-23
Product TypeVitamin
FormCapsule
BrandAdvanced Nutrition by Zahler
DSLD ID260230
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.